Duke faces a short recovery period after an emotional road win against a team that was tied with it near the top of the ACC.
The fifth-ranked Blue Devils look to maintain at least a share of the conference lead and notch a sixth straight victory Saturday when they host Virginia Tech.
Duke (24-4, 11-2) made 13 of 28 3-pointers in Thursday's 74-66 win at No. 15 Florida State, avenging a 76-73 home loss to the Seminoles on Jan. 21.
The Blue Devils moved back into a tie with No. 7 North Carolina for first place, while Florida State dropped one game back.
"We really just wanted to get a big win here," freshman guard Austin Rivers said. "We're not thinking about revenge. We're thinking about how they are tied with us at the top, or they were, us and Carolina."
Duke is 17-1 all-time at home against Virginia Tech (15-13, 4-9) heading into this noon EST contest. It beat the Hokies 75-60 in Blacksburg on Feb. 2.
"It's a quick turnaround," coach Mike Krzyzewski said. "We're beaten up a little bit and we're going to need a great crowd."
Rivers scored 18 points in the first meeting with the Hokies. He continues to lead all ACC freshmen with a 15.2 scoring average, and made four 3-pointers and scored 20 points Thursday.
"Throughout the game I thought Austin Rivers just played like a veteran," Krzyzewski said. "He had 20 points, wanted the ball at times when we had trouble scoring against them, he figured out how to score."
This matchup pits the ACC's top 3-point shooting teams, with Duke at 39.2 percent and Virginia Tech at 36.6.
The Blue Devils made 8 of 18 3-pointers in the first meeting while the Hokies were 3 of 13.
Virginia Tech turned in its worst defensive performance of the season Tuesday, allowing archrival and 25th-ranked Virginia to shoot 59.5 percent in a 61-59 home loss. That's the highest mark allowed by the Hokies over their last two campaigns.
The Hokies led by as many as nine, but were held to one basket over the final 13 minutes.
"It is astonishing," coach Seth Greenberg said. "We had some good looks. Obviously we got to the foul line and missed some free throws. We had scoring opportunities, quite honestly. We had scoring opportunities, but we just weren't as tough as we needed to be."
Erick Green was the only Virginia Tech player to reach double figures with 19 points. He's averaging 15.3 in three starts against Duke.
Virginia Tech has split its last four games, which have been decided by a total of five points. The Hokies appear to have one advantage, though, with two extra days off.
"Virginia Tech is fighting for everything," Krzyzewski said. "Like a lot of teams this year, they've had more preparation for the game we're playing in than we have. They played Tuesday night so they'll be fresh."
Hokies senior forward Victor Davila will likely miss his fourth straight game with a groin injury. Davila had 16 points and seven rebounds earlier this month against Duke.