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Teams seeded 13th or lower in the NCAA tournament have been first- or second-round "giant killers" 44 times since the field was expanded to 64 teams. Of those surprises, 32 have been decided by fewer than 6 points or in overtime.
| Year | Winner (Seed) | Loser (Seed) | Score |
| 2011 | Morehead State (13) | Louisville (4) | 62-61 |
| 2010 | Ohio (14) | Georgetown (3) | 97-83 |
| 2010 | Murray State (13) | Vanderbilt (4) | 66-65 |
| 2009 | Cleveland State (13) | Wake Forest (4) | 84-69 |
| 2008 | Siena (13) | Vanderbilt (4) | 83-62 |
| 2008 | San Diego (13) | Connecticut (4) | 70-69 (OT) |
| 2006 | Northwestern State (14) | Iowa (3) | 64-63 |
| 2006 | Bradley (13) | Kansas (4) | 77-73 |
| 2005 | Bucknell (14) | Kansas (3) | 64-63 |
| 2005 | Vermont (13) | Syracuse (4) | 60-57 |
| 2003 | Tulsa (13) | Dayton (4) | 84-71 |
| 2002 | UNC-Wilmington (13) | USC (4) | 93-89 (OT) |
| 2001 | Kent State (13) | Indiana (4) | 77-73 |
| 2001 | Hampton (15) | Iowa State (2) | 58-57 |
| 2001 | Indiana State (13) | Oklahoma (4) | 70-68 |
| 1999 | Weber State (14) | North Carolina (3) | 76-74 |
| 1999 | Oklahoma (13) | Arizona (4) | 61-60 |
| 1998 | Richmond (14) | South Carolina (3) | 62-61 |
| 1998 | Valparaiso (13) | Mississippi (4) | 70-69 |
| 1998 | SW Missouri State (13) | Clemson (4) | 65-60 |
| 1997 | Coppin State (15) | South Carolina (2) | 78-65 |
| 1997 | Tennessee-Chattanooga (14) | Georgia (3) | 73-70 |
| 1996 | Princeton (13) | UCLA (4) | 43-41 |
| 1995 | Weber State (14) | Michigan State (3) | 79-72 |
| 1995 | Old Dominion (14) | Villanova (3) | 89-81 (3OT) |
| 1995 | Manhattan (13) | Oklahoma (4) | 77-67 |
| 1993 | Santa Clara (15) | Arizona (2) | 64-61 |
| 1993 | Southern (13) | Georgia Tech (4) | 93-78 |
| 1992 | East Tennessee State (14) | Arizona (3) | 87-80 |
| 1992 | SW Louisiana (13) | Oklahoma (4) | 87-83 |
| 1991 | Richmond (15) | Syracuse(2) | 73-69 |
| 1991 | Xavier (14) | Nebraska (3) | 89-84 |
| 1991 | Penn State (13) | UCLA (4) | 74-69 |
| 1990 | Northern Iowa (14) | Missouri (3) | 74-71 |
| 1989 | Siena (14) | Stanford (3) | 80-78 |
| 1989 | Middle Tennessee State (13) | Florida State (4) | 97-83 |
| 1988 | Murray State (14) | North Carolina St. (3) | 78-75 |
| 1988 | Richmond (13) | Indiana (4) | 72-69 |
| 1987 | Austin Peay (14) | Illinois (3) | 68-67 |
| 1987 | Xavier (13) | Missouri (4) | 70-69 |
| 1987 | SW Missouri State (13) | Clemson (4) | 65-60 |
| 1986 | Cleveland State (14) | Indiana (3) | 83-79 |
| 1986 | Ark.-Little Rock (14) | Notre Dame (3) | 90-83 |
| 1985 | Navy (13) | Louisiana State (4) | 78-55 |
