Lee suffered a sprained knee in the 62-41 loss to Arizona State, and interim coach Ed Orgeron said Monday that Lee's status for the game against the Wildcats is "very questionable."
The Trojans' wide receiver told reporters last week that he was "getting better daily" and seemed hopeful to play against Arizona with a bye week to aid in his return. Lee's absence puts even more pressure on Nelson Agholor, one of the few truly healthy scholarship wide receivers on the roster.
The Arizona game could be the 2013 debut for injured running back Silas Redd. Redd, the Trojans leading rusher a year ago with 905 yards on the season, suffered a knee injury in spring practice and has undergone two surgical procedures. He has been cleared to play, but told reporters he will have to "ease into things."
Redd's appearance could help boost depth at running back, where sophomore Tre Madden and freshman Justin Davis have carried much of the load. USC's practice notes from Monday indicate that Davis participated on a limited basis due to an ankle injury. Madden is averaging over 100 yards per game and Davis has taken advantage of his limited action, averaging 7.40 yards per carry and racking up three touchdowns in the loss to Arizona State.