Offensive coordinator Clay Helton, serving as USC's interim coach for the bowl, told reporters on Saturday that the status of Redd's knee injury is "worse than expected."
"Silas' knee is probably worse than expected," Helton said via the Los Angeles Times. "I don't think he's going to make it right now from what it sounds like."
Redd was on the sideline for Saturday's practice with fellow running back Tre Madden. Madden, the team's leading rusher on the season with 703 yards, has been bothered by an ankle injury and could be a game-time decision for the bowl game.
A left knee injury in spring practice caused Redd to miss the start of the 2013 season after leading USC in rushing in 2012, then this current setback was caused by a right knee injury against California on Nov. 9.
Sophomore Javorius Allen is expected to start at running back against Fresno State on Saturday. Injury issues at the position opened the door for Allen in the last month of the season, and the sophomore responded by rushing for more than 120 yards in four of the Trojans' final five games.
For predictions, matchups to watch and more on the Las Vegas Bowl check out the CBSSports.com Bowl Preview.