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Lee made the announcement on Twitter Friday night.
"I have decided to forego my senior season at USC and declare for the 2014 NFL Draft," tweeted Lee. "I want to thank my coaches, teammates, staff and the entire Trojan Family for all of the support over the last three seasons. I am a proud Trojan and will remain a Trojan for life!"
Lee battled through injuries in 2013, finishing the season with 57 catches for 791 yards and four touchdowns. However, he won the Biletnikoff Award as a sophomore in 2012, and finished his first two seasons with the Trojans having caught 191 passes for 2,864 yards and 25 touchdowns.
In other words, he was a beast for the Trojans, and a player they're going to miss.
Lee is projected as a first round pick.