Garrison sprained his anterior cruciate ligament in his left knee during practice Friday and sustained a slight medial collateral ligament sprain as well in the knee.
The true freshman had a team-leading 742 yards, and scored six touchdowns this season.
"It's an unfortunate situation for Dustin, but it is one that we will have to deal with as a team," coach Dana Holgorsen told reporters.
"This marks our third key player out for the bowl game with a knee injury, but I expect our team to maintain its focus as we prepare for Clemson," Holgorsen told reporters.
The Mountaineers could have depth issues at running back in the bowl game. Junior Shawne Alston, who's run for 339 yards, for a 4.4 per-carry average, and 10 touchdowns, should be the main ballcarrier.
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