| Week 13 - Wednesday, Nov. 18, 2009 |
| Buffalo Bulls at Miami (Ohio) RedHawks |
 Buffalo 21 |  Miami (Ohio) 17 |
| Central Michigan Chippewas at Ball State Cardinals |
 Central Michigan 28 |  Ball State 13 |
| Week 13 - Thursday, Nov. 19, 2009 |
| Colorado Buffaloes at Oklahoma State Cowboys |
 Oklahoma State 31 |  Colorado 14 |
| Week 13 - Friday, Nov. 20, 2009 |
| Akron Zips at Bowling Green Falcons |
 Bowling Green 34 |  Akron 20 |
| Eastern Michigan Eagles at Toledo Rockets |
 Toledo 26 |  Eastern Michigan 14 |
| Boise State Broncos at Utah State Aggies |
 Boise State 45 |  Utah State 14 |
| Week 13 - Saturday, Nov. 21, 2009 |
| Minnesota Golden Gophers at Iowa Hawkeyes |
 Iowa 24 |  Minnesota 16 |
| Louisville Cardinals at South Florida Bulls |
 South Florida 27 |  Louisville 17 |
| Ohio State Buckeyes at Michigan Wolverines |
 Ohio State 27 |  Michigan 14 |
| Duke Blue Devils at Miami (Fla.) Hurricanes |
 Miami (Fla.) 35 |  Duke 20 |
| Maryland Terrapins at Florida State Seminoles |
 Florida State 31 |  Maryland 23 |
| North Carolina Tar Heels at Boston College Eagles |
 Boston College 21 |  North Carolina 20 |
| Chattanooga Mocs at Alabama Crimson Tide |
 Alabama 38 |  Chattanooga 10 |
| Mississippi State Bulldogs at Arkansas Razorbacks |
 Arkansas 34 |  Mississippi State 24 |
| Oklahoma Sooners at Texas Tech Red Raiders |
 Oklahoma 42 |  Texas Tech 28 |
| Florida International Golden Panthers at Florida Gators |
 Florida 49 |  Florida International 13 |
| Memphis Tigers at Houston Cougars |
 Houston 37 |  Memphis 17 |
| Kent State Golden Flashes at Temple Owls |
 Temple 34 |  Kent State 20 |
| TCU Horned Frogs at Wyoming Cowboys |
 TCU 41 |  Wyoming 13 |
| Iowa State Cyclones at Missouri Tigers |
 Missouri 33 |  Iowa State 21 |
| Tulane Green Wave at UCF Knights |
 UCF 31 |  Tulane 20 |
| Northern Illinois Huskies at Ohio Bobcats |
 Northern Illinois 28 |  Ohio 23 |
| Connecticut Huskies at Notre Dame Fighting Irish |
 Notre Dame 28 |  Connecticut 24 |
| Oregon Ducks at Arizona Wildcats |
 Oregon 38 |  Arizona 31 |
| Air Force Falcons at Brigham Young Cougars |
 Brigham Young 30 |  Air Force 23 |
| Baylor Bears at Texas A&M Aggies |
 Texas A&M 27 |  Baylor 17 |
| Texas-El Paso Miners at Rice Owls |
 Texas-El Paso 21 |  Rice 18 |
| Wisconsin Badgers at Northwestern Wildcats |
 Wisconsin 28 |  Northwestern 20 |
| LSU Tigers at Mississippi Rebels |
 LSU 24 |  Mississippi 21 |
| North Carolina State Wolfpack at Virginia Tech Hokies |
 Virginia Tech 28 |  North Carolina State 17 |
| Rutgers Scarlet Knights at Syracuse Orange |
 Rutgers 28 |  Syracuse 14 |
| Penn State Nittany Lions at Michigan State Spartans |
 Penn State 31 |  Michigan State 24 |
| Purdue Boilermakers at Indiana Hoosiers |
 Purdue 24 |  Indiana 23 |
| UAB Blazers at East Carolina Pirates |
 East Carolina 31 |  UAB 17 |
| Virginia Cavaliers at Clemson Tigers |
 Clemson 34 |  Virginia 20 |
| San Diego State Aztecs at Utah Utes |
 Utah 30 |  San Diego State 13 |
| Arizona State Sun Devils at UCLA Bruins |
 UCLA 28 |  Arizona State 23 |
| Army Black Knights at North Texas Mean Green |
 Army 24 |  North Texas 13 |
| Florida Atlantic Owls at Troy Trojans |
 Troy 33 |  Florida Atlantic 19 |
| Southern Methodist Mustangs at Marshall Thundering Herd |
 Marshall 34 |  Southern Methodist 27 |
| Arkansas State Red Wolves at Middle Tennessee Blue Raiders |
 Middle Tennessee 31 |  Arkansas State 17 |
| Louisiana Tech Bulldogs at Fresno State Bulldogs |
 Fresno State 28 |  Louisiana Tech 22 |
| Oregon State Beavers at Washington State Cougars |
 Oregon State 35 |  Washington State 10 |
| Colorado State Rams at New Mexico Lobos |
 Colorado State 24 |  New Mexico 17 |
| Tulsa Golden Hurricane at Southern Mississippi Golden Eagles |
 Southern Mississippi 34 |  Tulsa 31 |
| Louisiana-Monroe Warhawks at La.-Lafayette Ragin Cajuns |
 Louisiana-Monroe 24 |  La.-Lafayette 19 |
| Vanderbilt Commodores at Tennessee Volunteers |
 Tennessee 28 |  Vanderbilt 12 |
| California Golden Bears at Stanford Cardinal |
 Stanford 38 |  California 30 |
| Kansas State Wildcats at Nebraska Cornhuskers |
 Nebraska 27 |  Kansas State 17 |
| Kentucky Wildcats at Georgia Bulldogs |
 Georgia 28 |  Kentucky 23 |
| Hawaii Warriors at San Jose State Spartans |
 Hawaii 26 |  San Jose State 23 |
| Kansas Jayhawks at Texas Longhorns |
 Texas 42 |  Kansas 21 |
| Nevada Wolf Pack at New Mexico State Aggies |
 Nevada 34 |  New Mexico State 13 |
