Bills' IK Enemkpali: Leaves game with "major knee injury"

Enemkpali suffered what Bills head coach Rex Ryan is calling a "major knee injury" during Saturday's preseason game against the Colts, Mike Rodak of ESPN.com reports.

Enemkpali went down in the second quarter as he was engaged with a blocker while rushing Indianapolis quarterback Scott Tolzien. The injury further depletes the Bills' depth at outside linebacker. Rookie first-round pick Shaq Lawson is out until Week 6 at the earliest after undergoing shoulder surgery in May while veteran Manny Lawson remains out with a partially torn pectoral muscle.