American midfielder Sacha Kljestan scored in the ninth minute and Anderlecht went on to a 6-0 win at Ekranas of Lithuania on Wednesday night, advancing to the final round of qualifying for the Champions League.
Kljestan also assisted on the second goal for Anderlecht, which won the home-and-home, total-goals series on 11-0 aggregate.
The 20 teams in the playoff round will be drawn into 10 series on Friday. The playoff winners will join the 22 clubs that qualified directly for the group stage.
Scottish champion Glasgow Celtic won 2-0 at HJK Helsinki on goals by Joe Ledley in the 67th minute and Giorgos Samaras in the 86th for a 4-1 aggregate victory. Panathinaikos beat Scotland's Motherwell 3-0 for a 5-0 aggregate win.
Also advancing were Basel (Switzerland), Cluj (Romania), Copenhagen (Denmark), Dinamo Zagreb (Croatia), Fenerbahce (Turkey), Helsingborg (Sweden), Kiryat Shmona (Israel), AEL Limassol (Cyprus) and Maribor (Slovenia). Dynamo Kiev (Ukraine) and BATE Borisov (Belarus) advanced on Tuesday.
Six teams start play in the final qualifying round: Borussia Moenchengladbach, Braga, Lille, Malaga, Spartak Moscow and Udinese.