Matt Howard had the first buzzer-beater, Morehead State has the first upset.
Demonte Harper knocked down a pull-up 3-pointer with 3.6 seconds left to beat fourth-seeded Louisville, 62-61.
The Cardinals had a chance to win it on a last-second shot, but Kenneth Faried made a terrific defensive play to block Mike Marra's 3-point attempt.
In such a volatile year, this could be the first of many Round of 64 upsets.
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