Yankees manager Joe Girardi confirmed it during his pre-game media session Saturday afternoon, adding that Chad Gaudin will be available in relief.
Sabathia will be pitching on short (three days') rest, something with which he has had great success in the past.
"This is the World Series," Girardi said. "There's no baseball after the World Series for four or five months, so there will be plenty of time to rest.
"I think the important thing on short rest is you have to know how your pitcher is feeling physically. We talked, and he threw pretty good game after short rest [in Game 4 of the AL Championship Series against the Angels]."