Jaguars QB Blaine Gabbert vs. Panthers QB Cam Newton -- Yeah, they won't face each other. But this is a battle of two rookie passers taken in the top-10 of the draft last April. Newton is off to a fast start. Gabbert will be making his first start. It will be interesting to see how he responds. The other question is this: Can Newton keep it up?
Cardinals WR Larry Fitzgerald against Seahawks CB Brandon Browner -- Fitzgerald had one big play last week against DeAngelo Hall, but it was a 73-yard touchdown catch. Browner had a real tough go of it against the Steelers. If Fitzgerald can get man coverage against him -- even though he's a bigger corner at 6-4 -- he should light him up.
Ravens OLB Terrell Suggs vs. Rams T Rodger Saffold -- Suggs didn't do much last week against Titans left tackle Michael Roos. Saffold is one of the rising stars at left tackle. He did a nice job on Jason Pierre-Paul Monday night. This will be a real challenge and chance to earn some acclaim for Saffold.
Redskins CB DeAngelo Hall vs. Cowboys QB Tony Romo -- Anytime a player talks about going after another player's injury, it has to make this list. Romo has a broken rib and Hall said he would do his best to get a shot on it if he could. He might want to worry more about covering Romo's receivers. Hall is off to a great start this season, but making the statement he did is risky business.
Giants defensive front against Eagles offensive line -- The last time the Giants played Mike Vick, they attacked him from all angles. That will put a lot of pressure on the Eagles re-shuffled line. Can rookie center Jason Kelce handle the line calls to help identify the blitzers? Pierre-Paul vs. Jason Peters should be a fun battle.
Saints QB Drew Brees against Texans top-ranked pass defense -- The Texans haven't exactly played two good passing offenses, but they did finish last in 2010 and now they're first in pass defense. But Brees and his receivers will be a big challenge to that rating. It's hard to get pressure on Brees because he gets the ball out so quickly. That will put a lot of pressure on the cover people on the back end.
Steelers OLB James Harrison vs. Colts LT Anthony Castonzo -- Anytime a pass rusher like Harrison faces a rookie tackle, it makes for interesting talk. Harrison is one of the toughest players in the NFL, but Castonzo won't back down. He's a tough guy too.
Jets C Colin Baxter vs. Raiders DTs Richard Seymour and Tommy Kelly -- Baxter, an undrafted rookie, will be making his first NFL start for the injured Nick Mangold. That's tough on the road against two good tackles. The Jets are a run-heavy team and if they are to have success doing that Baxter has to have a good game.
Bengals LT Andrew Whitworth vs. 49ers DE Justin Smith -- This is a battle of two former teammates who are both relentless in their play. Smith has started to get his due, but it's time Whitworth get some as well. He did a nice job last week against the Broncos and he can get more juice if he plays well against Smith.
Bills WR Stevie Johnson vs. Patriots CB Devin McCourty -- Johnson has become a top-level receiver. McCourty is one of the best young corners. When they get matched up, it will be interesting to see who wins. Johnson is a smart receiver who knows how to run routes. He isn't a burner, but he plays fast. He is bothered some by a groin injury, but is expected to play McCourty excels in man coverage. Keep an eye on this one.