As has become the norm, the American League dominated the National League during interleague play in 2012. In 252 interleague games, the AL went 142-110 (MLB.com). That is a .563 winning percentage -- which amounts to a 91-71 record over the course of 162 games.
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The American League has now "won" interleague play every season since 2003 and holds a .525 all-time winning percentage in interleague play (MLB.com).
So what does this all mean? Well, not that much. I guess you could say bragging rights among fans, but anyone being honest and objective can tell that the American League houses more talent and overall has more good teams. And this does nothing to prevent the National League from winning the All-Star Game (which it did the past two seasons) or the World Series (which it did the past two seasons and three of the past four).
This was the last season that we'll be able to judge the "winner" of interleague play in June. Starting next season, the Astros will move to the American League West, giving each league 15 teams -- which means there will have to be at least one interleague series all season.