UPDATE: Calhoun will miss 4-6 weeks with a bad ligament sprain, according to Jeff Fletcher of the Orange County Register.
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Calhoun sustained the injury while running to first base in extra innings against the Athletics on Tuesday night. Here's the play in question:
Calhoun had to be helped off the field, and, as MLB.com's Alden Gonzalez writes, he was on crutches after the game.
This is a blow for the Angels, as the 26-year-old Calhoun, who has a strong minor-league track record, was coming off a quality 2013 season for the Angels and slugging .500 in the early going this year.