Davis looks to continue the hot hitting that has aided Baltimore's longest winning streak over its AL East rivals in 16 years as the Orioles open a three-game set at Yankee Stadium on Friday night.
After completing a four-game sweep in Minnesota with Thursday's 9-5 victory, the Yankees (46-39) have a chance to equal their season-best winning streak as they begin a stretch of 10 straight at home.
They also won five in a row May 8-12.
The four consecutive wins over the Twins followed three straight losses in Baltimore during which New York was outscored 19-8.
"We're going home for a long stretch, and we're taking some momentum with us," Thursday's winner David Phelps said. "It would've been real easy to take what happened in Baltimore and carry it over here."
Davis pounded New York pitching in the final two games of that series, hitting three homers with six RBIs to lead the Orioles (48-38) to their fourth and fifth consecutive wins against the Yankees.
The first baseman, who ranks among the major league leaders with a .327 average and 83 RBIs and tops all players with 32 homers, is 9 for 21 with five home runs and nine RBIs in his last six games versus New York.
Now he'll try to help Baltimore extend its longest winning streak against the Yankees since an eight-game run bridging the 1996 and 1997 seasons.
Davis, though, hasn't had the same type of success at Yankee Stadium, where he's hitting .228 with four homers and 17 RBIs in 27 games.
Scheduled New York starter Ivan Nova (2-2, 4.63 ERA) makes only his second start since April as he fills in for Hiroki Kuroda, who may only miss one outing due to a hip injury.
Nova struck out seven and allowed three runs over 6 2-3 innings in his last spot start, a 3-1 loss to Tampa Bay on June 23.
The right-hander is 0-2 with a 10.26 ERA in his last three starts against the Orioles. He also worked 5 2-3 innings of relief, giving up two runs in an 11-3 loss at Baltimore on Saturday.
Davis went deep off Nova in that appearance and is 6 for 16 with two homers and seven RBIs lifetime in this matchup.
Teammate Matt Wieters should be happy to see Nova again, since he's 9 for 21 with three homers and three doubles against him.
Baltimore, which dropped two of three to the last-place White Sox to open its road trip, appears to have a solid opportunity to bounce back behind right-hander Miguel Gonzalez (6-3, 3.77).
Since allowing a season-worst five earned runs over six innings against Detroit on May 31, Gonzalez has gone 4-1 with a 2.88 ERA in five starts.
He's 2-1 with a 2.70 ERA in four career starts versus the Yankees, allowing four earned runs over 13-plus innings for an 0-1 record in two starts against them this season.
He'll have to contend with Robinson Cano, who was 14 for 24 with four homers and 10 RBIs over a six-game stretch before going 0 for 4 Thursday.
Cano is hitting .410 with two homers and six RBIs in his last 10 games against Baltimore.
Although the Orioles have won six of nine in the season series, the Yankees took two of three at home in April.