Tampa Bay looks to complete a three-game sweep of the Orioles by winning for the seventh time in eight games Wednesday night.
The Rays had dropped five straight contests away from home - their longest road skid since 2009 - before winning Monday's series opener 4-3 behind a two-run homer from Matt Joyce and a solo shot from Evan Longoria.
Joyce, who had five RBIs in his previous 28 games combined, then drove in three runs as Wil Myers added a pair of RBIs in Tuesday's 7-4 victory to help Tampa Bay (72-52) win for the fifth straight time in Baltimore.
The Rays, who lead the AL wild-card race and are competing with Boston for the East division lead, have won six of seven overall following a six-game losing streak.
"It's very big for where we're at in the division and the fact we're chasing the Red Sox a little bit and also trying to create some distance, because we know the O's and the Yankees are very capable and very tough competitors,'' said Ben Zobrist, who had two hits and an RBI. "We don't anticipate it being any sort of easy road to the end of September. This is two great wins for us to start off.''
Baltimore (67-58), meanwhile, has lost six of eight and sits 5 1/2 games behind Tampa, which has won seven of the last eight meetings overall. Matt Wieters hit a two-run homer in the ninth Tuesday to pull the Orioles closer, but they couldn't overcome the Rays' four-run top half of the inning.
Wieters is 16 for 48 with five of his 19 homers and 14 RBIs in the season series. He's a career .337 hitter with 15 home runs in 69 games against Tampa Bay.
Teammate Chris Davis singled, walked and was hit by a pitch, but he's just 2 for 22 (.091) in his last six versus the Rays. He hit .483 with four homers, four doubles and 15 RBIs in the first eight meetings this season.
Baltimore will look to get back on track with help from Wei-Yin Chen, who has been solid recently against the Rays.
Chen (6-6, 3.23 ERA), though, has lost three straight starts while posting a 4.66 ERA after allowing four runs in 6 1-3 innings of Friday's 6-3 loss to Colorado. He gave up at least three runs for the fifth consecutive outing despite striking out seven and retiring 12 of the first 13 hitters he faced.
"I feel bad because it's my fault," Chen said. "I couldn't keep the guys in the ballgame. But tomorrow is another day.''
The left-hander is 1-1 with a 1.69 ERA over the last four times he's faced the Rays, though. Chen allowed two runs in 5 2-3 innings before Tampa Bay rallied for an 8-7 win April 3. He opposed Jeremy Hellickson in that contest and will do so again Wednesday.
Hellickson (10-6, 4.91) gave up five runs and eight hits in six innings versus the Orioles in April before allowing a career worst-tying eight runs in 7 2-3 innings of a 12-10 win May 17.
The right-hander's last outing against Baltimore went much better, as he gave up four hits in six innings of an 8-0 victory June 8. Hellickson, though, is 0-3 with an 8.00 ERA over his last four starts after giving up three runs in six innings of Tampa Bay's 5-4 win over Toronto on Friday.
Hellickson is 8-3 with a 3.09 ERA in 14 career starts versus the Orioles, who have lost five of seven at home.