Robinson Cano and Ichiro Suzuki have had a major role in that staggering success.
While Cano looks for another big effort at the plate, Suzuki has a chance to reach 4,000 career hits as the Yankees attempt to beat the Blue Jays in the Bronx for the 12th straight time Wednesday night.
New York (66-59) has won 11 of the past 12 meetings with Toronto, including eight in a row. The Yankees have been particularly dominant at home against the Blue Jays, winning 20 of 22 and 11 straight for the longest such streak by either team in the all-time series.
They kept that streak going by sweeping a doubleheader Tuesday, winning 8-4 in the opener before Jayson Nix's walk-off single capped a 3-2 win in the nightcap. He tied the score with a solo homer in the seventh.
Cano was also impressive in the twinbill, getting six hits with a double, a homer and five RBIs as he continued to torment Blue Jays pitching. He's batting .381 with 25 RBIs over the last two seasons against them, including a .459 average while driving in 17 runs over his last 15 matchups.
Ichiro Suzuki is hitting .366 against Toronto (57-69) since being acquired from Seattle last year. He had a single and a double in Monday's series opener, leaving him one shy of 4,000 combined hits during his careers in Japan and the majors.
The right fielder's 2,721 hits since 2001 are 374 more than anyone else.
"I didn't have 4,000 hits in my whole career, and you can go back to tee ball," manager Joe Girardi told the team's official website. "To me, it's an unbelievable feat. He's some kind of hitter."
Girardi will give the ball to Andy Pettitte (8-9, 4.39 ERA) in the hopes that he can build on Friday's 10-3 win at Boston. The left-hander didn't allow an earned run for the first time this season, as all three he gave up over 6 2-3 innings came courtesy of two errors by Eduardo Nunez.
"It was one of those nights where I felt like everything was working," Pettitte said.
Pettitte is 3-1 with a 3.13 ERA over his last five starts against Toronto, winning both meetings at home while yielding three runs in 11 innings.
The Blue Jays, losers of three in a row, will turn to R.A. Dickey (9-11, 4.49). He's allowed seven runs and 12 hits in 14 innings while not getting a decision over his last two starts. He was 1-0 with a 0.66 ERA over his two previous outings - both Jays wins.
The right-hander seemed to be headed for a victory Friday, allowing one run in five innings before giving up three in the next two of a 5-4 loss at Tampa Bay.
Dickey was charged with a 3-2 loss at Yankee Stadium on April 28, giving up three runs and two homers in seven innings. The 27 homers he's served up on the season are a career high and rank among the most in baseball.
Dickey has limited Cano to 3 for 13 in their matchups while Suzuki is 2 for 13. Both are 0 for 3 this year.
At a combined age of 79, Pettitte and Dickey are the two oldest starters to square off in the majors this season.