The injury-plagued outfielder also attempts to help the red-hot Tyson Ross bounce back from a hard-luck defeat Monday night, while Arizona's Brandon McCarthy tries to continue his dominance against San Diego.
After missing four consecutive games with a sore right groin, Quentin hit a pinch-hit, two-run homer in a 3-2 loss to the Chicago Cubs on Saturday. He produced an RBI single in his lone at-bat Sunday that helped provide San Diego (23-28) enough cushion to hold on for a 4-3 victory.
Quentin has appeared in just six games this season mainly because of an ailing left knee but is 6 for 14 (.429) with two homers and five RBIs. He also hit a pinch-hit homer in an 8-5 win in Colorado on May 17 and is 3-for-3 in that role.
"He's feeling better so we think he'll be good to go tomorrow," manager Bud Black said.
A matchup with Arizona could prove ideal for Quentin's return. He's is batting .400 (10 for 25) with a 1.163 OPS in his last seven games against the team he played with in his first two seasons.
Quentin is also hitting .400 (14 for 35) with a 1.202 OPS in his last 10 games at Chase Field.
Ross (5-4, 2.64 ERA) has also fared well against the Diamondbacks (20-32), going 1-1 with a 1.86 ERA in four starts. He gave up three runs - one earned - in seven innings May 4 in his lone meeting this season, a 4-3 victory that allowed the Padres to avoid a three-game home sweep.
That outing began a four-game stretch in which he's given up one earned run over seven innings, going 2-1 with a 1.29 ERA. He allowed three hits for the second straight game while striking out eight for the third consecutive start Wednesday against Minnesota, but suffered a 2-0 defeat.
McCarthy (1-6, 4.67) earned his lone win of the season against the Padres on May 3, pitching seven scoreless innings in a 4-3 victory. The right-hander has given up one run in each of his last two games, a combined 14 innings, but has not received decisions while getting one total run of support.
He pitched six innings in St. Louis on Wednesday but exited with Arizona trailing 1-0 in a 3-2 loss in 12 innings.
The Diamondbacks don't appear poised to provide McCarthy with too much help in this game either. They batted .159 and scored 11 runs on a 2-4 road trip, with Paul Goldschmidt going 5 for 24 with eight strikeouts.
Arizona still managed to win the first two games against the New York Mets this weekend before losing 4-2 in the finale of Sunday's doubleheader. The Diamondbacks went 0 for 13 with runners in scoring position during those two games.
"We're in a funk. We're not swinging the bats well at all. We didn't really give ourselves much of a chance," manager Kirk Gibson told the team's website. Our pitching was pretty decent. You can't expect to win every game 2-1."
McCarthy is 3-1 with a 1.67 ERA in four career starts against San Diego. He has allowed one run or fewer and pitched seven innings in three of those games.
Goldschmidt is 5 for 12 against the Padres this season - including a homer off Ross. He is 4 for 11 with two home runs and a triple in his career against the right-hander.