Zack Greinke is with his fourth team and he's never won any of six previous starts against clubs he has left.
Greinke (12-7, 2.71 ERA) is 0-3 with a 4.75 ERA against teams he has faced since leaving them - Kansas City, Milwaukee (64-52) and the Los Angeles Angels.
The right-hander enters off one of those such outings Monday when he allowed five runs in seven innings in a 5-0 home defeat to the Angels.
Greinke made his return to Miller Park on May 21, 2013, and allowed five runs over four-plus innings in a 5-2 defeat, failing to retire the five hitters he faced in the fifth. It marked his first start against the Brewers, the team with which he went 16-0 in 25 home outings - two in the postseason - from 2011-12.
He figures to face a stern test against Lyle Overbay, who is 9 for 26 with three homers against him. Left fielder Gerardo Parra is 8 for 24 in the regular season against Greinke.
It's not clear if Greinke will face Jonathan Lucroy, who went 2 for 3 off him in last season's matchup. Lucroy was held out of Friday's opener with a hamstring strain.
"He's got a little bit of a hamstring issue," manager Ron Roenicke told MLB's official website. "It's there. I'm being cautious with it. I don't want him to miss time."
This matchup of division leaders began with Milwaukee rallying for a 9-3 victory Friday. Dodgers shortstop Justin Turner had two errors in the seventh that led to three unearned runs before the Brewers' Rickie Weeks drilled a three-run homer in the eighth.
''Actually, it was a pretty good game there until the seventh,'' Dodgers manager Don Mattingly said. ''Then, we just defensively let our pitching down really."
Turner was in the game only because Hanley Ramirez was removed by Mattingly in the first inning because of tightness in his right side. Ramirez is listed as day to day.
''One swing, it just tightened up on me,'' Ramirez said. ''What he (Mattingly) did is smart. He don't want to make it worse."
Adrian Gonzalez was 3 for 3 with his 16th homer for Los Angeles (66-51), which had a three-game win streak snapped.
Gonzalez is a career .393 hitter with eight home runs in 22 career games in Milwaukee.
The Brewers will give Mike Fiers (0-1, 2.57) his first start since June 2, 2013. He is starting since Matt Garza is on the disabled list with a left oblique strain.
Fiers has spent most of 2014 in the minors, making four June appearances for Milwaukee. He is 8-5 with a 2.55 ERA in 17 starts for Triple-A Nashville.
"I think Fiers, with the way he's been throwing in Triple-A this year, we know what he did for us when we first had him up and what kind of starts he got," Roenicke said.
The right-hander made first career start May 29, 2012, against the Dodgers, yielding one run over seven innings in a 2-1 road win.