Gagne gave up ninth-inning home runs to Chipper Jones and Andruw Jones -- his first two batters since coming off the disabled list -- and the Braves beat the Los Angeles Dodgers 5-1 on Saturday night.
"I'm sure they were going to put him in the game no matter what, because he wanted to face some major-league players after facing just minor-league guys," said Andruw Jones, who also homered against Odalis Perez and drove in three runs.
"Gagne's a tremendous pitcher. I mean, saving 80-something games in a row is amazing. But today he just left a couple of pitches up and over the plate and we took care of them."
Aside from J.D. Drew's RBI single in the sixth, the only thing the Dodger Stadium crowd of 49,112 had to cheer about was the season debut of Gagne, who lumbered in from the bullpen to the strains of Welcome to the Jungle on the public address system.
But those cheers quickly died down when Chipper Jones drove a 3-1 pitch over the center field fence and Andruw Jones hit an 0-2 delivery to left-center field for his eighth homer.
"I wasn't nervous -- maybe anxious," said Gagne, who missed the first 35 games because of a sprained right elbow. "It was my mechanics. I felt great. I hadn't pitched in a game in six or seven months. It was great to face major-league hitters again, and I got my feet wet. I'm just going to have to step it up now."
Gagne, who entered the game with the Dodgers trailing 3-1, struck out his last three batters after giving up the two homers and a single by Julio Franco.
"It was an appropriate enough situation to have him pitch," pitching coach Jim Colborn said. "I don't think he was in his best rhythm and form until later in the inning. I look at the quality of the pitches, not so much the results. And he threw some good pitches there towards the end."
"That was a beauty tonight," manager Bobby Cox said. "The bullpen pieced it together."
Hampton, off to a 4-1 start and coming off a two-hit shutout against Houston last Sunday, threw 40 pitches in 2 1/3 innings. The two-time All-Star, in his third season with the Braves, has a 1.96 ERA this season and is 15-2 in 22 starts since last July 4.
"It was a spasm-type thing," Cox said. "It just tightened up. His whole forearm was just hard as a rock. He had the same thing last year at one time last year, and it took him a little while to get it going again. But he should be perfectly OK for his next start -- we think. He was smart enough to know when to shut it off."
Mondesi, who began his career with the Dodgers and was the NL rookie of the year in 1994, hit a two-out homer to left field in the fifth against Perez (4-4). The left-hander lost his third straight start, allowing three runs, five hits and no walks in six innings while striking out six.
Andruw Jones made it 3-0 in the sixth with a two-out drive that hooked around the left field pole, making him only the 14th player to hit a fair ball into Dodger Stadium's loge deck in the ballpark's 44-year history. He batted cleanup for the 14th time in 36 games.
"No matter where you're hitting in the lineup, if you're feeling good at the plate, it doesn't matter," Jones said. "Tonight I was surprisingly in the cleanup spot, but I'll take it. I had a couple of chances to drive in some runs, and I did. I just want to have a good approach at the plate."
The Dodgers got a run back in the bottom half on a double by Jason Repko and a single by Drew -- only his fourth hit in 28 at-bats this season with runners in scoring position.
Atlanta opened the scoring in the first when Marcus Giles singled, advanced on a single by Chipper Jones, stole third and scored on Andruw Jones' sacrifice fly.
The Dodgers threatened in the bottom half. But Bradley, who homered from both sides of the plate Friday night and hit a go-ahead grand slam, struck out with two men on base. Hampton, who surrendered 25 first-inning runs in his 29 starts last season, has allowed only one in eight starts this season.
- Cox didn't arrive in the dugout until just after Hampton's departure. Cox was in Northern California attending a family funeral.
- RHP John Smoltz, the only player left from the 1991 team that began Atlanta's record streak of 13 division titles, turns 38 years old on Sunday.
- Cox's managerial record against the Dodgers is 126-105, including a three-game sweep in the 1996 NL Division Series. The three-time NL manager of the year turns 64 next Saturday.
- Saturday was a special anniversary for Colborn, who threw the only no-hitter of his big-league career on May 14, 1977, for the Kansas City Royals against the Texas Rangers.