Renteria hit a grand slam, Ramirez got four singles, and Boston battered New York pitching Saturday for a 17-1 rout that snapped a season-high, four-game losing streak.
"Our offense took it personally today. This offense, we haven't even seen what they're going to do," Clement said. "We had to respond because the Yankees are playing so good right now."
Johnny Damon also had four hits and scored three times, and John Olerud had three hits in his first major-league game since last fall. It was Boston's largest margin of victory over the Yankees, surpassing a 15-1 win on Sept. 1, 1990, at Fenway Park, according to the Elias Sports Bureau.
"It's kind of obvious that we needed that," manager Terry Francona said. "Not only to win, but to have a little bit of room there, to take some deep breaths and let our staff pitch."
Carl Pavano (4-3) and Paul Quantrill were roughed up for the Yankees, who had their five-game winning streak snapped and lost for only the third time in 19 games. They had won nine consecutive games at home.
The 27 hits were the most for the Red Sox since they tied the club record of 28 on June 27, 2003, against Florida. Pavano started that game as well, for the Marlins, and failed to get an out.
"It's got to be tough to watch if you're out there standing behind me," Pavano said. "It's not what I had anticipated."
All the offense made it tough on the scoreboard operator at Yankee Stadium -- the board went blank for a few moments in the eighth inning as the Red Sox piled on. New York allowed its most hits since giving up a franchise-record 28 on Sept. 29, 1928, in a 19-10 loss at Detroit.
"We'll look for a pick-me-up tomorrow," Yankees manager Joe Torre said. "Hopefully, we'll get back on track and play the type of baseball we've been used to the last three weeks. You've got to brush it off."
The Red Sox had been held to three runs or fewer in three consecutive games for the first time since August 2003. But they set a season high for hits by the fifth inning behind Ramirez and Renteria, who finished with five RBIs.
Booed in Boston as he got off to a slow start in his first season with the team, Renteria is 12-for-19 on the current road trip, raising his average to .281.
"Edgar's got a big game he can play, just a matter of time with him," teammate Jason Varitek said. "He's traditionally too good a player. Confidence is a beautiful thing."
Ramirez's big game snapped a 1-for-16 skid. He hit just .193 in his previous 31 games, a slump that dropped his average to .224.
Pursued by Boston last offseason, Pavano gave up five runs and a season-high 11 hits -- 10 singles and a double. He lost for the first time in eight starts since April 15 at Baltimore and was booed off the mound by a disappointed crowd of 55,315.
Clement (6-0) struck out his first three batters, then worked out of trouble the rest of the afternoon. He allowed five hits in six shutout innings, striking out seven and walking four.
Ramirez and Nixon hit consecutive RBI singles with two outs in the fourth for a 5-0 lead, chasing Pavano.
Three straight Red Sox singles in the fifth chased Mike Stanton, and Renteria sent Quantrill's second pitch over the right-field fence for his fourth career slam.
After Ramirez singled for his fourth consecutive hit, Nixon made it 12-0 with a three-run shot to center.
"I was terrible," Quantrill said. "I didn't have anything."
Jay Payton, who replaced Ramirez in left field in the sixth, added a two-run drive off Quantrill in the seventh.
- Boston scored 16 runs against the Yankees on Aug. 12, 1937, at Fenway.
- Olerud made his first start at 1B for Boston and singled to right in his first at-bat. He finished 3-for-6 but could have had five hits -- he hit two balls that deflected off the pitcher for groundouts. "It's just a good way to start things off," he said. "Definitely nervous for the first little bit. Everybody else has two months under their belt. This is like opening day for me. You're with a new club, you want to do well."
- The 19-game season series is tied 4-4.
- Renteria's previous grand slam came on June 9, 2004, with St. Louis at Wrigley Field.
- Derek Jeter was hit in the back by Clement's pitch in the third. He left for a pinch-hitter in the fifth with New York down 12-0.
- Red Sox C Kelly Shoppach made his major-league debut when he came in to catch in the seventh.