Guerrero had three hits and scored three runs, a more modest offensive output than teammates Steve Finley and Darin Erstad, who each homered in the Angels' 12-2 win over the New York Mets on Friday night.
Bartolo Colon won his fourth straight decision in Guerrero's first game since the reigning AL MVP partially dislocated his shoulder May 20.
"He makes everyone around him better. There's no question what he does to a lineup," Angels manager Mike Scioscia said. "It's not going to relate to 12 runs all the time."
Colon (8-3) wound up outpitching Mets starter Kazuhisa Ishii, and has four wins in six starts since losing May 7 to Detroit. He went six innings, allowing just two runs on seven hits. He struck out three with no walks.
Ishii (1-5) was overpowering his first two times through the Angels' order. The left-hander threw first-pitch strikes to 17 of 18 batters, and lefties looked particularly uncomfortable against him.
His promising night came to a quick halt in the sixth, shortly after he had to run the bases. He gave up a four-pitch walk to Chone Figgins and allowed a tying homer to Erstad, who struck out his first two times up, lunging awkwardly at a pitch far outside the zone his second time.
"That might have been the best five innings that we've had pitched against us in a while," Scioscia said.
"Stamina wasn't the problem," Ishii said through an interpreter.
Mets manager Willie Randolph said Ishii's spot in the rotation was not in immediate jeopardy, despite his rough turn in the sixth.
"It was kind of puzzling to have him go like that so quickly," Randolph said. "Maybe the inning before took a lot out of him running the bases, I don't know. I would hate to think that's the case."
Finley, who went 3-for-4 with a sacrifice fly, drove in four runs and has 16 RBI in his past 13 games. Erstad's homer extended his hitting streak to 11 games. Orlando Cabrera added a three-run shot off Manny Aybar in the ninth that just eluded leaping left fielder Cliff Floyd's glove.
Ishii struck out a season-high nine and walked just two in 5 2/3 innings. He gave up five runs on six hits. For the first five innings, anyway, it was a promising effort from a pitcher who began the night with more walks (23) than strikeouts (20).
Colon, meanwhile, was simply efficient. Like Ishii, he threw first-pitch strikes to 22 of 25 batters, but he limited the damage to Jose Reyes' RBI single in the third and Miguel Cairo's sacrifice fly in the fifth.
"My mentality was to throw strikes," Colon said through an interpreter.
Colon added an RBI single off DeJean in the sixth. It was the first multihomer inning of the season for the Angels, who have been hitting well over .300 in the past two weeks.
Joel Peralta pitched two innings in of relief of Colon, who came out after only 88 pitches because of the humidity and previous high pitch-count outings. Esteban Yan finished up the victory, which was the Angels' ninth in 14 games.
"The guys have been going good without me," Guerrero said through an interpreter.
The Angels were playing their first series against the Mets at Shea, but visited Flushing for a game against the Yankees in 1998, when Yankee Stadium was declared unsafe because a 500-pound, steel-and-concrete joint had crashed from the upper deck while the ballpark was empty.
- The Angels placed RHP Kelvim Escobar back on the 15-day DL because of a bone spur in his right elbow.
- Colon's helmet flew off his head twice as he swung at pitches in the third inning.
- It was Greek Night at Shea. The nearby Queens neighborhood of Astoria is home to a large population of Greek immigrants.
- Dallas McPherson broke his bat grounding out in the fifth inning. The shattered barrel of the bat careered through the infield and came to rest upright, with the shattered point sticking into the infield grass.