On the first pitch after Chicago third baseman Joe Crede dropped his foul pop-up for an error, Ramirez homered in the ninth, sending the Boston Red Sox to a 6-5 win and giving Curt Schilling his first victory as a reliever since 1992.
"That was huge. This was a game of little things," said Schilling, who blew the save when Crede hit a two-out, game-tying double in the eighth, then got his first win since April 18, when he was a starter.
"A foul ball gets dropped and that is the difference in the game," Schilling said.
Crede couldn't hang on to the high pop-up near the third base stands when the ball drifted back toward the field. It ended his 49-game streak without an error and gave Ramirez another chance.
"You just knew once Crede dropped that ball that Manny was going to do something special," Boston's Johnny Damon said.
Ramirez sent his 26th homer to left center off Luis Vizcaino (4-4) and Boston had just its fourth win in the last 10 games.
Crede's error was the third of the game for the White Sox, helping the Red Sox to three unearned runs.
"Our defense was not what we've played all year long. Joe has been playing good. It was not an easy play," Chicago manager Ozzie Guillen said.
Ramirez did not comment after the game.
Crede's error couldn't have come at a worse time for the White Sox, who have lost three straight, all at home.
"It's a humbling feeling. You got to keep your head up," Crede said.
"The people in the stands were looking like they were ready to grab for it. When I looked for the railing I saw them getting ready to grab it and all of a sudden it drifts back. But it's a routine play I should make."
The White Sox tied it in the eighth when Aaron Rowand doubled with one out, went to third on an infield out and scored on Crede's two-out double.
"I'm incredibly disappointed. I forgot the feeling of letting down your starter and your team," Schilling said after his fifth relief appearance. "That's probably why I'm so upset about it. It's an adjustment."
Chicago starter Mark Buehrle gave up 10 hits and five runs -- three earned -- in six-plus innings.
Damon scored all the way from second with a hard slide and when Iguchi's throw got by catcher A.J. Pierzynski for a second error, Renteria and Ortiz moved up.
Ramirez was intentionally walked to load the bases before Cliff Politte relieved Buehrle and struck out Jason Varitek. But Millar hit a fly ball to right to score Renteria. Ortiz was thrown out at third by right fielder Timo Perez on the play just after Renteria had crossed the plate.
Carl Everett hit his 14th homer, a two-run shot in the first that just cleared the center field fence, for a 2-0 lead. It came after Scott Podsednik singled leading off and then stole his major league-leading 49th base.
Paul Konerko and Rowand added solo shots in the fourth to give the White Sox a 4-1 lead. Konerko's homer was his 22nd and Rowand's his sixth and first since June 12.
Boston cut the lead to two in the fifth when Damon doubled and scored when Renteria's long liner to center went off Rowand's glove for another double. Moments after a high tight pitch, Ortiz punched an RBI single to left that ticked Crede's glove and cut the lead to 4-3.
In the second, Varitek singled, Trot Nixon reached on an infield hit and Bill Mueller hit an RBI double. Nixon attempted to score from third on Tony Graffanino's bouncer to short but Juan Uribe easily threw him out.
- Clement has given up seven homers in his last three starts after yielding just six in his first 17 outings.
- Buehrle was the sixth straight left-hander faced by the Red Sox, the first time that's happened since 1914.
- Buehrle has pitched at least six innings in 48 straight starts.
- Perez walked after a 12-pitch at-bat against Clement in the sixth.
- The White Sox are considering putting DH Frank Thomas on the disabled list with a sore ankle, Guillen said after the game.