SEATTLE -- Shawn Chacon put the New York Yankees into too much of a hole to climb out of.
Ichiro Suzuki hit a three-run homer in a five-run second inning, and the Seattle Mariners beat the Yankees 8-3 Tuesday night.
New York, 1-1 on a seven-game trip, dropped 2½ games behind the Boston Red Sox in the AL East. The Yankees, who overcame a four-run deficit against the last-place Mariners in Monday's 7-4 win, lead Cleveland by half-game in the wild-card race and are one game in front of the Los Angeles Angels.
"I stunk," said Chacon, whose ERA nearly doubled from 1.80 to 3.13 in his seventh start with the Yankees. "I got behind in the count early all night long and made it hard for myself. I didn't make the pitches when I had to."
Before the game, the Yankees learned Mike Mussina will miss at least one start because of slight inflammation on the inside of his pitching elbow, becoming the fifth and final member of the New York Yankees' original starting rotation to get hurt this year.
Chacon (3-2), one of the pitchers imported by the Yankees to patch their rotation, had his worst start with New York, allowing eight runs, eight hits and four walks in six innings. He also hit two batters and threw a run-scoring wild pitch.
"For some reason, it looked like he was rushing it tonight," Yankees manager Joe Torre said. "It was all about command. He just couldn't get strike one."
Jeff Harris (2-1) allowed three runs, six hits and five walks in 6 1/3 innings, stopping the Yankees' five-game winning streak. The 31-year-old rookie, signed by Seattle as a minor league free agent in December, made his third major league start.
"Except for getting married, it's the highlight of my life so far," Harris said. "It's really fun to go out there and compete against one of the best teams and organizations in the history of the game."
Mariners manager Mike Hargrove liked what he saw.
"I don't know that he was awe-struck, but he was terribly excited," Hargrove said.
Alex Rodriguez hit his AL-leading 40th homer and joined Joe DiMaggio as the only right-handed hitters to reach 40 homers with the Yankees. DiMaggio hit 46 in 1937.
Rodriguez reached 40 for the seventh time in eight seasons and has 25 homers against Seattle, his original major-league team, including four this season. He played with a tight right groin and started at designated hitter for the first time this season.
After the game, Rodriguez talked to reporters with his right leg wrapped in a big bag of ice.
"Any time you get mentioned with Joe DiMaggio with the rich tradition of the Yankees, you feel humbled," said Rodriguez, who said someone had retrieved the home-run ball.
He said he was unsure if he could play at third base on Wednesday night. He went 1-for-2 with three walks, getting ready for his at-bats in the clubhouse.
"It's going to be totally up to Joe," Rodriguez said. "I guess we'll have to see when I wake up in the morning."
Former Red Sox rival Mark Bellhorn, signed earlier in the day, took over at third base and went 0-for-4 at the plate.
"I wasn't too nervous," he said. "I hadn't played for a while, but the guys made me very comfortable here. Now, I just want to do what this team needs."
Richie Sexson scored the game's first run with a headfirst slide on Chacon's wild pitch. Yorvit Torrealba followed with an RBI grounder, and Suzuki homered for the second straight night and 15th time this season.
Chacon said Suzuki's homer that made the score 5-0 did him in. He said he threw a changeup on a 3-1 pitch.
"I didn't get the pitch where I wanted to," Chacon said. "It wasn't that bad of a pitch, but he's a great hitter."
Jorge Posada singled in a run and Matt Lawton had an RBI groundout in the Yankees' two-run third, but Jose Lopez hit a two-run double in the bottom half and scored on Yuniesky Betancourt's double for an 8-2 lead.
Rodriguez homered leading off the fifth.
The Yankees' Derek Jeter had his 1,900th career hit, a sixth-inning single. ... Lawton's throwing error from right field in the third ended a string of nine errorless games and 90 errorless innings for the Yankees. ... The only other major leaguers to hit 40 in seven seasons were Babe Ruth (11), Hank Aaron and Harmon Killebrew (eight) and Barry Bonds, Ken Griffey Jr. and Sammy Sosa (seven). ... New York's Randy Johnson, who won his first of five Cy Young Awards with the Mariners in 1995, is to pitch for the Yankees Wednesday night in only his second career start at Safeco Field. His first start was July 20, 1999, a complete-game shutout in a 6-0 Arizona win. He is scheduled to face Mariners 19-year-old rookie sensation Felix Hernandez.