Garcia won his sixth consecutive decision, leading the White Sox to a 7-3 victory over the Twins on Monday to salvage a split of the four-game series.
Unlike Sunday night's win, in which they gave up seven runs in the first inning and later pulled off a triple play to rally, the White Sox never trailed this time.
Garcia (6-1) pitched 6 2/3 reliable innings, giving up three runs and seven hits, including a home run by Torii Hunter.
Scott Baker (1-4) was roughed up for Minnesota, whose starters have a collective 6.51 ERA, the worst in either league.
"That's what sets the tone. Always has, always will in this game," manager Ron Gardenhire said.
Justin Morneau drove in Hunter with a sacrifice fly in the second inning, and Hunter's leadoff shot in the fourth brought the Twins to 4-2. But Garcia retired eight in a row after that, breezing to the victory. He left after an RBI single by Shannon Stewart in the seventh, striking out three and walking one.
"I threw strikes. I tried to make my pitches, and that's all I can do. ... We've got five guys in the rotation. We can go every day and try to win some games," Garcia said.
"Obviously, we were in position to take the series, and right now it's a little frustrating," Minnesota's Joe Mauer said.
The Twins needed a strong start from Baker -- especially with everyone else in the rotation not named Johan Santana still struggling to find their form. Before the game, righty Carlos Silva was sent to the bullpen temporarily to give him more time to straighten himself out. Budding star lefty Francisco Liriano will fill his spot for now.
Baker quickly fell behind, despite handling the heart of the Chicago order -- Jim Thome and Paul Konerko -- without a problem. It was the leadoff man, Podsednik, and a pair of light-hitting subs who did him in.
Widger and Mackowiak, a reserve outfielder, entered the game with only 16 hits -- three for extra bases -- and eight RBI in 82 at-bats between them.
"We continue to work hard off the field, between batting practice and extra hitting, to try to stay in game shape," Mackowiak said. "And when we get in there, hopefully we can be productive."
Widger drove in Mackowiak with a single in the second, and Podsednik homered on a full-count pitch two batters later that clanked on the top of the stacks of football seats above right field and made it 3-0.
"These guys on the bench did a tremendous job," manager Ozzie Guillen said.
Podsednik, who went deep twice in the postseason, including a shot that ended Game 2 of the World Series, last homered in the regular season on Sept. 30, 2004, for Milwaukee. This was his first home run in 162 regular-season games with the White Sox, and he grinned as he reached the dugout and received a congratulatory helmet slap from Thome.
Gardenhire used an off day to keep Santana on schedule, pushing Baker back by three days.
"You might not be as sharp," Baker said, "but there's no excuse not to throw the ball down."
Chicago had at least two runners on in every inning, and Widger led off the fourth with his homer. In the fifth, Crede singled and scored on Widger's single.
That summoned Willie Eyre to relieve Baker, who gave up a career-high 11 hits, five runs and one walk in 4 2/3 innings while striking out four. Eyre loaded the bases in the sixth, and Crede drove in Podsednik with a sacrifice fly to make it 6-2.
"We don't want to leave here being swept or lose the series," Guillen said. "Every time we come to Minnesota, I almost say the same stuff. Those guys just keep battling. They never make you relax."
- In 14 games batting fourth, Hunter is batting .382 (21-for-55) with three homers and 16 RBI.
- The Twins had four steals in as many tries. Widger has thrown out only one runner stealing in nine attempts this year.
- Morneau turned 25 on Monday.
- Mackowiak brought a 1-for-17 slump into the game.