Ortiz and Ramirez hit two of Boston's four homers and drew two of its three bases-loaded walks to lead the Red Sox over the Tigers 8-3 Sunday.
"This was an important series, and the next one is an important series," Red Sox manager Terry Francona said.
Detroit only trailed 5-3 going into the eighth, but three pitchers combined to walk four batters and hit another in a 50-pitch inning.
Jason Grilli failed to retire any of the four batters he faced. He hit Youkilis to load the bases, then walked Ortiz, Ramirez and Trot Nixon before being pulled from the game.
"I failed out there today," he said. "I need to be better than that."
Tigers manager Jim Leyland was ejected for arguing balls and strikes during the walk to Ramirez.
"I'm never going to talk about umpires," he said. "We just didn't throw strikes."
Detroit has lost six of eight, including five of seven in back-to-back series against the Yankees and Boston.
"This was kind of a blah homestand," Brandon Inge said. "We didn't play very well, which is funny to say, because not very well this year was really, really good in past years."
Matt Clement (5-4) allowed three runs and six hits in six innings to get the win. He struck out five, walked two and left with a 2-1 count to Detroit's leadoff hitter in the seventh. The Red Sox said the unusual departure, which was instigated by catcher Jason Varitek, was due to fatigue.
"Tek didn't like what he saw," Francona said. "If that runner had reached base, he was coming out anyway."
Clement felt he probably worked too hard after a pair of poor starts.
"I did a lot more throwing, and I think that's why I tuckered out," he said. "It was a good start, though. All of my pitches were better."
Gonzalez hit a two-run drive off Zach Miner in the second inning to give Boston a 2-0 lead. The Red Sox then loaded the bases with two outs in the third before Miner (0-1) induced J.T. Snow to line out to left to end the inning.
The Tigers cut it to 2-1 on Ivan Rodriguez's RBI single in the fourth, but the Red Sox added two more in the fifth inning.
Youkilis led off with his second homer in three games to make it 3-1 and chase Miner from the mound. Jamie Walker relieved and allowed Ortiz's 436-foot drive to right-center field.
Miner allowed three runs and seven hits with two walks in four-plus innings in his major league debut.
"I felt great, but I was just out of whack mechanically," he said. "That's probably the best-hitting team in baseball, and they just wouldn't swing at anything out of the strike zone."
Rodriguez had an RBI groundout and Marcus Thames doubled in a run in the sixth to get Detroit within one again but Ramirez made it 5-3 with a two-out homer off Roman Colon in the seventh.
Magglio Ordonez nearly made it 8-5 in the bottom of the eighth, but Coco Crisp made a leaping catch at the center-field wall to take away a two-run homer.
|Alex Gonzalez (right) gets props from Jason Varitek after ripping a two-run blast in the second inning. (AP)|
|Players of the Game|
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|Boston Red Sox|
|Coco Crisp, CF||5||0||0||0||0||1||2||.278|
|Kevin Youkilis, 3B||4||2||2||1||0||2||0||.313|
|Mike Lowell, 3B||0||0||0||0||0||0||0||.320|
|David Ortiz, DH||2||1||1||2||3||0||0||.261|
|Manny Ramirez, LF||4||1||1||2||1||1||3||.297|
|Willie Harris, LF||0||0||0||0||0||0||0||.176|
|Trot Nixon, RF||3||0||1||1||1||1||2||.296|
|Jason Varitek, C||5||1||3||0||0||0||4||.245|
|J.T. Snow, 1B||4||1||0||0||1||0||5||.206|
|Alex Gonzalez, SS||5||1||1||2||0||0||1||.225|
|Alex Cora, 2B||5||1||2||0||0||0||0||.278|
|HR - Kevin Youkilis (7, Miner), David Ortiz (16, Walker), Manny Ramirez (14, Colon), Alex Gonzalez (3, Miner)|
|RBI - Kevin Youkilis (27), David Ortiz 2 (50), Manny Ramirez 2 (37), Trot Nixon (30), Alex Gonzalez 2 (16)|
|2-OUT RBI - David Ortiz (18), Manny Ramirez 2 (15), Trot Nixon (13)|
|SB - Kevin Youkilis (3, 2nd base off Miner/V. Wilson)|
|CS - Alex Cora (2, 2nd base by Miner/V. Wilson)|
|Team LOB - 10|
|Outfield Assists - Manny Ramirez 1|
|DP - Snow-A. Gonzalez|
|Boston Red Sox|
|Matt Clement (W,5-4)||6||6||3||3||2||5||0||6.68|
|Jermaine Van Buren (H,1)||1||1||0||0||1||1||0||1.23|
|WP - Rudy Seanez (4)|
|Pitches-Strikes - Matt Clement 93-60, Jermaine Van Buren 33-21, Rudy Seanez 12-11, David Riske 13-9|
|Ground Balls-Fly Balls - Matt Clement 8-3, Jermaine Van Buren 1-1, David Riske 1-0|
|Batters Faced - Matt Clement 24, Jermaine Van Buren 5, Rudy Seanez 4, David Riske 3|
|Curtis Granderson, CF||3||2||2||0||1||1||0||.283|
|Marcus Thames, DH||4||0||1||1||0||2||3||.313|
|Ivan Rodriguez, 1B||4||0||2||2||0||0||0||.309|
|Magglio Ordonez, RF||3||0||1||0||1||0||2||.321|
|Carlos Guillen, SS||3||0||0||0||1||1||3||.298|
|Craig Monroe, LF||4||0||0||0||0||1||3||.237|
|Brandon Inge, 3B||4||0||0||0||0||1||0||.214|
|Ramon Santiago, 2B||4||0||0||0||0||2||0||.174|
|Vance Wilson, C||4||1||2||0||0||1||0||.295|
|2B - Curtis Granderson (12, Clement), Marcus Thames (9, Clement)|
|RBI - Marcus Thames (15), Ivan Rodriguez 2 (25)|
|Team LOB - 6|
|Zach Miner (L,0-1)||4||7||3||3||2||2||2||6.75|
|HBP - Nixon (by Bobby Seay), Youkilis (by Jason Grilli)|
|Pitches-Strikes - Zach Miner 87-47, Jamie Walker 12-8, Roman Colon 10-5, Bobby Seay 21-14, Jason Grilli 21-6, Chris Spurling 15-9|
|Ground Balls-Fly Balls - Zach Miner 1-8, Jamie Walker 1-4, Chris Spurling 1-3|
|Batters Faced - Zach Miner 20, Jamie Walker 8, Roman Colon 3, Bobby Seay 6, Jason Grilli 4, Chris Spurling 4|
|Attendance - 35764|
|Game Time - 3:26|
|Temperature - 80|
|Umpires - Home - Paul Nauert, First Base - Larry Vanover, Second Base - Greg Gibson, Third Base - Scott Barry|