TORONTO -- R.A. Dickey pitched into the seventh inning, Jose Reyes sparked Toronto's offense and the Blue Jays snapped a 10-game losing streak against the New York Yankees with a 5-2 victory on Monday night.
Alex Rodriguez hit his 650th home run, a leadoff drive in the fifth, but the Yankees lost for the ninth time in 13 road games this month. Rodriguez is 10 homers away from tying Willie Mays for fourth on the career list, which would secure a $6 million bonus for the third baseman.
Derek Jeter went hitless in his return to New York's lineup. Jeter, who started at shortstop and batted second, finished 0 for 3 with a walk, grounding into a double play in the third.
Reyes walked and scored in the third, and doubled and scored in Toronto's three-run fifth as the Blue Jays beat the Yankees for just the second time in 14 meetings this season. Toronto had lost 10 straight to its division rival since an 8-4 home victory on April 21.
Dickey (10-12) allowed two runs, one earned, and six hits in 6 1/3 innings to win for the first time since Aug. 5 at Seattle. The knuckleballer was 0-1 with a 4.50 ERA in his three previous starts.
It was Dickey's first victory against the Yankees since May 21, 2011, when he played for the New York Mets.
Rodriguez's home run was the 29th allowed by Dickey this season, second only to Oakland's A.J. Griffin. Dickey has given up 20 home runs in 14 home starts.
Aaron Loup worked 1 1/3 innings, Sergio Santos got one out in the eighth and Casey Janssen finished for his 24th save in 26 chances.
New York right-hander Phil Hughes (4-13) allowed five runs, four earned, and seven hits in 4 2/3 innings. He is 0-6 with a 5.84 ERA in his past nine starts.
New York scratched out a run in the first when Brett Gardner singled, went to second on a passed ball, took third on Jeter's grounder and scored when Dickey couldn't handle Robinson Cano's comebacker.
The Blue Jays tied it in the second on an RBI single by Kevin Pillar, and then took the lead on Edwin Encarnacion's RBI single in the third.
Rodriguez connected in the fifth, but Toronto responded with three in the bottom half, taking advantage of a rare error by Ichiro Suzuki.
Reyes hit a one-out double, Ryan Goins singled and Reyes scored when Suzuki couldn't handle Encarnacion's fly to deep right, with the ball hitting off the heel of his glove.
Adam Lind followed with an RBI double and Brett Lawrie was intentionally walked to load the bases for Moises Sierra, who chased Hughes with a sacrifice fly. David Huff came on and fanned Josh Thole on three pitches.
Blue Jays OF Colby Rasmus (strained left oblique) is still feeling soreness and was unable to resume baseball activities as previously scheduled, manager John Gibbons said. Rasmus has been out since Aug. 12. ... Toronto reinstated Loup from the paternity list and designated RHP Chien-Ming Wang for assignment. ... Blue Jays Triple-A C Sean Ochinko was suspended 50 games after testing positive for amphetamines. ... Musician Paul Simon attended the game.