Shin-Soo Choo and Joey Votto homered on Monday as Cincinnati roughed up Wainwright for the second start in a row, and Mat Latos went the distance for the first time this season in a 7-2 victory over the Cardinals.
Latos (14-5) credited an offense that seems to have Wainwright's number.
"It doesn't matter who we're playing, but there's definitely more of an anxiety added when you have a guy like Wainwright," said Latos, who allowed four hits. "We were fortunate to be able to get to him today."
Fortunate? Or maybe they've figured him out?
"I don't know about that," said Ryan Ludwick, who singled home a run. "I think we've gotten some pitches to hit the last two outings we've faced him, and we've done damage."
Latos gave up a pair of singles and a sacrifice fly by Matt Holliday in his fourth career complete game.
The third-place Reds are trying to end the Cardinals' season-long dominance during their four-game series at Great American Ball Park. St. Louis has won the past seven series between the teams and is 10-6 against Cincinnati this year.
"It starts at one," Reds manager Dusty Baker said. "Hopefully this is just a beginning because we've got a lot of work to do, a long way to go."
The Cardinals took two of three in St. Louis last week, the only loss coming when the Reds tagged Wainwright (15-9) for nine runs in a career-low two innings. They hit him hard again on Monday, piling up six runs and 10 hits in six innings.
Wainwright isn't sure what's going on with him and the Reds.
"The last time, it was a matter of me leaving too many ball in the middle of the plate," Wainwright said. "Today, they hit some good pitches. I feel very strong. I've had some good games against them in the past. It's a head-scratcher, to be honest with you."
It's an important series for Cincinnati, which now trails the Cardinals by 2½ games. St. Louis opened the day tied with Pittsburgh for first place. The Reds maintain a comfortable lead for the final NL wild-card spot.
The last time the Cardinals visited Great American Ball Park, they won by scores of 13-3 and 15-2 during a one-sided series that left the Reds embarrassed. This one started much better for them.
Wainwright fell to 5-9 career against Cincinnati. In his past two starts against the Reds, the right-hander has given up 18 hits and 15 runs in only eight innings. He's 1-3 in four starts against Cincinnati this season with a 7.77 ERA.
"That's a real good pitcher," Baker said. "We have nothing but respect for Wainwright. He's not the guy that you would exactly choose to face twice a week. It's a funny game."
Cardinals catcher Yadier Molina came out of the game in the fifth inning because of a sore left wrist. He was activated off the 15-day disabled list on Aug. 15 after missing 14 games with a sore right knee.
The Reds quickly got to Wainwright. Choo opened the first with a single and scored on Ludwick's two-out single. Ludwick missed more than three months with torn cartilage in his right shoulder, but the left fielder is starting to get his swing back in shape. Ludwick has driven in a run in each of his past four games.
Zack Cozart singled home a run in the second, and Choo's two-run homer made it 4-0. Choo leads all major-league leadoff hitters with 19 homers. He has three homers during a six-game hitting streak, which includes four multihit games.
Votto hit an up-and-away 1-2 pitch to the opposite field in left for his 21st homer in the fourth inning.
- Cardinals RF Carlos Beltran's back was still sore Monday, prompting manager Mike Matheny to keep him out of the starting lineup for a second straight day as a precaution. "Instead of trying to push him through, we've tried to pay attention to how he feels," Matheny said. "That should pay dividends in the long run."
- St. Louis 1B Matt Adams extended his slump to 0 for 14.
- The Reds called up OF Billy Hamilton and INF Neftali Soto and activated C Corky Miller off the 15-day DL before the game.
- Homer Bailey (9-10) tries to extend his winning streak -- 4-0 in his past six starts -- against the Cardinals' Michael Wacha (2-0), who makes his fifth career start.