ST. PETERSBURG, Fla. -- Yu Darvish showed no rust after missing three weeks.
"He was in control of the game," Rangers manager Ron Washington said. "He was using his pitches. He was throwing strikes. And that's what he does."
Darvish (1-0) struck out six and walked one. Sidelined by neck stiffness, it was his first outing since a spring training game on March 16.
"I didn't feel anything unusual," Darvish said through an interpreter.
Darvish got his 500th career strikeout, coming in 401 2-3 innings, by fanning David DeJesus and Wil Myers in the first. According to the Rangers, it is the fewest innings for a starter to reach 500 strikeouts in major league history.
"He's going to get five a year, and today was one of them," Washington said of Andrus' homer. "It was huge. We needed it. Today, he drove the bus."
Alex Cobb scattered three hits, walked one and struck out six in seven shutout innings for the Rays.
"Unfortunately for us, he was really on," Cobb said of Darvish.
Only one runner reached second against Cobb.
"He didn't give up any pitches," Andrus said. "I thought he was painting the whole game. I'm really glad that we had Yu out there. He was doing the same thing for us."
Tampa Bay had runners on second and third with one out in the fifth, but failed to score when Myers hit an infield pop fly and Ben Zobrist flew out.
"We just did not get the knocks when we needed it," Tampa Bay manager Joe Maddon said.
The Rays were hitless in 10 at-bats with runners in scoring position against Darvish, and 0 for 11 overall.
"As usual, you've got a team over there that fights forever," Washington said. "They put themselves in some good positions to score some runs, but Yu made the pitches when he had to."
Darvish was activated from the 15-day disabled list and RHP Nick Martinez was optioned to Double-A Frisco. ... Rangers RHP Colby Lewis (hip surgery) gave up four runs and four hits over five innings in a rehab start for Triple-A Round Rock. ... Texas LHP Joe Saunders (bruised left ankle) is not expected to be ready for his regular bullpen session Monday and could miss his next start. ... Texas RHP Tanner Scheppers (0-0) will face Boston RHP John Lackey (1-0) Monday night in the opener of a three-games series at Fenway Park. ... Tampa Bay LHP Matt Moore (0-1) and Royals LHP Jason Vargas (0-0) are the scheduled starters for Monday night's game in Kansas City.