Holt made his first professional start in center field and he appeared perfectly comfortable in his fifth position this season. He made a sensational diving catch to end the third inning and scored both Boston runs in the Red Sox's 2-1 win over the Minnesota Twins 2-1 on Tuesday night.
"It seems like Brock at some point in each game has an effect on what's going on," said Jon Lester, who weathered a shaky start and pitched six-plus strong innings. "I'm sure we'll see him with catcher's gear or on the mound at some point this year. The guy's done an unbelievable job."
Holt ended the third inning with a diving catch on a ball that left fielder Jonny Gomes lost in the twilight. Gomes signaled with his hands that he couldn't see it, but Holt was already on the move and lunged just in time to complete the catch.
"Fortunately I was able to get over there and make a play," Holt said.
Boston fans gave him a long ovation during his entire trot to the dugout, and teammates waited with high-fives and pats on the back on the way.
Holt happened to be up next and led off with a double off the Green Monster, stole third and scored on a sacrifice fly to put the Red Sox up 2-0.
"He comes out of nowhere and makes a diving catch. In a way, he took over the inning," Boston manager John Farrell said. "He doesn't get hung up on moving to a position for the first time. He goes out and plays."
Holt scored Boston's first run after he singled and then came in on an RBI double by Dustin Pedroia.
Lester (8-7) needed 33 pitches to get out of the first inning on a hot, muggy night, then settled down and took a shutout into the sixth. He left with one out in the seventh after striking out six and holding the Twins to one run, four hits and a walk.
Edward Mujica pitched the ninth and earned his second save.
Phil Hughes (7-3) took the loss for the Twins, who have dropped four straight. The Red Sox have held Minnesota to one run and seven hits in the first two games of the series.
Hughes gave up two runs and eight hits in eight innings and struck out six.
"He did all he could do. He gave us a great opportunity to win. We just couldn't come up with enough big hits," manager Ron Gardenhire said.
Minnesota cut it to 2-1 in the sixth when Santana led off with a double, moved to third on a bunt by Brian Dozier, and scored on Joe Mauer's double.
"We need to knock in some runs," Gardenhire said. "We need more of them."
Pedroia nearly broke open the game on a fly ball to left that was inches short of a two-run homer. Instead, it was a single, and Pedroia was caught in a rundown. The play was reviewed for several minutes, and the call on the field stood.
Holt played center field on Tuesday and has made starts in all three outfield positions, as well as first and third base. ... Lester struck out Eduardo Escobar in the fifth inning for his 1,342nd career strikeout, passing Cy Young for fourth place on Boston's career strikeout list. ... Lester threw nearly one-third of his 109 pitches in the first inning. ... Before the game, the Red Sox designated outfielder Grady Sizemore for assignment. Sizemore returned from injuries that sidelined him between September 2011 and this season. He hit .333 in spring training, but struggled lately. In 52 games, he hit .216 with two homers and 15 RBI. ... Minnesota RF Oswaldo Arcia went 0-for-4 and is hitless in 20 at-bats. ... Minnesota RHP Kyle Gibson (6-5, 3.55) will face Boston RHP John Lackey (8-4, 3.24) in the finale of the three-game series on Wednesday afternoon.