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| All-Time Pitching Leaders | ||
| Career Losses Leaders | ||
| Rank | Player | L |
| 1. | Cy Young | 315 |
| 2. | Pud Galvin | 302 |
| 3. | Nolan Ryan | 292 |
| 4. | Walter Johnson | 279 |
| 5. | Phil Niekro | 274 |
| 6. | Gaylord Perry | 265 |
| 7. | Don Sutton | 256 |
| 8. | Jack Powell | 253 |
| 9. | Eppa Rixey | 251 |
| 10. | Bert Blyleven | 250 |
| 11. | Warren Spahn | 245 |
| Robin Roberts | 245 | |
| 13. | Early Wynn | 244 |
| Steve Carlton | 244 | |
| 15. | Jim Kaat | 237 |
| 16. | Frank Tanana | 236 |
| 17. | Gus Weyhing | 234 |
| 18. | Tommy John | 231 |
| 19. | Ted Lyons | 230 |
| Bob Friend | 230 | |
| 21. | Greg Maddux | 227 |
| 22. | Ferguson Jenkins | 226 |
| 23. | Red Ruffing | 225 |
| 24. | Tim Keefe | 223 |
| 25. | Bobo Newsom | 222 |
| Active players shown in CAPS | Last Updated: Fri May 25 08:15:04 EDT 2012 | ||
