Stroman tossed two scoreless innings before Tampa Bay knocked in two runs in the third inning. Tampa Bay added another run in the fourth on Jeremy Moore's leadoff home run.
Stroman has allowed at least two runs in each of his three spring appearances. He has an 8.00 ERA and seven strikeouts in nine innings.
De La Rosa would likely have served as the second starter, but Jhoulys Chacin is destined to begin the season on the 15-day disabled list with a right shoulder issue.
The former has yielded just one run in his last six innings of exhibition play after a rough first start.
After holding Toronto to one hit in two scoreless innings in his previous appearance, Karns made his first start of the spring Wednesday, holding Toronto to three hits and one walk in 3 1/3 scoreless innings. He had one strikeout.
Karns has not allowed a run in 6 1/3 innings, while giving up just four hits and two walks. He has three strikeouts.
The neck problem lingered longer than anticipated after he was first scratched on Saturday. Zobrist was supposed to play Monday, but continued to be pushed back.
It was an improvement for Worley, who was tagged for five runs and seven hits in 1 1/3 innings in his previous spring appearance. However, it's been all downhill for him since opening the spring with three scoreless innings March 3 against the Orioles. Worley has a 10.13 ERA through three appearances.
Correia was hit hard Wednesday, surrendering four runs on seven hits in three innings. He managed just one strikeout.
The Pirates jumped on Correia for a run in the top of the first inning, but Minnesota quickly tied the game in the bottom of the first. However, Pittsburgh broke open the game with a three-run third inning, which featured a two-run homer off the bat of Pedro Alvarez. Correia's ERA jumped to 6.00.
Bud Black has not placed a timetable on the return of third baseman
Headley took a huge step back in 2013 after a breakout season in which he batted .286 with 31 home runs and 115 RBI. He batted just .250 with 13 home runs and 50 RBI a year ago. His .400 slugging percentage consistituted nearly a 100-point drop from the previous season.
On Wednesday, Cole allowed one unearned run on three hits and one walk, while striking out three in three innings. He lowered his ERA to 3.60.
That improvement apparently happened quickly. Bruce Bochy said Tuesday at Scutaro was not yet close to such activity. His status for opening day has now brightened markedly. Back and finger issues had kept him sidelined throughout spring training.
Jimenez was shaky from the start Wednesday, as three of the first five batters reached base. Domonic Brown then unloaded a two-out, bases-clearing triple to give Philadelphia an early lead. Jimenez wasn't much better in the second inning, surrendering one run on one walk and two triples.
"It was a tough day," Jimenez said, per MLB.com. "The first time I got to pitch from the stretch in a game and it got the best of me. I couldn’t find a good release. When I got from the stretch. And that was after the leadoff guy got on base right away, so it was a little bit tough to get in a good rhythm.”
Jimenez's ERA jumped from 0.00 to 9.00 in his second spring start.