Hernandez (5-4), who made his 11th start of the season, surrendered a run-scoring single to Jurickson Profar and a two-run double to David Murphy in the second. He served up a solo home run to Nelson Cruz in the fifth and was charged with five runs on 11 hits and one walk while striking out nine over 5 2/3 innings of work.
Hernandez has allowed 11 runs -- 10 earned -- over his last two starts (11 innings). It's the most runs he has allowed between two starts since September of 2012. He will try to get back on track Thursday at San Diego. He went 1-1 with a 4.15 ERA in his last two starts against the Padres.
Nathan needed just 11 pitches as he retired the side in order to secure a 5-2 win. His ERA improved to 1.86 after making his fifth consecutive scoreless appearance. He has converted his last 17 save opportunities dating back to last season.
Holland allowed two unearned runs in the third inning for his only damage of the night. He retired 12 of the final 15 batters he faced and was charged with two unearned runs on four hits and three walks over 6 2/3 innings of work in a 5-2 victory.
Holland has allowed one earned run or fewer in three of his last five starts. He is scheduled to make his next start Thursday at home against Arizona. He is 1-1 with a 2.60 ERA in four starts at home.
Cabrera had never homered more than twice in a season entering 2013, hitting just five home runs in 296 career games. He's hit four homers in 48 games this season and has five multi-hit performances in his last seven games to boost his batting average to .267.
Miley has now given up 15 earned runs in 14 2/3 innings over his last three starts, taking the loss in each to drop to 3-4 on the year. He and his 4.53 ERA are scheduled to face the Rangers in Arlington Thursday.
Cashner pitched to one batter in the seventh inning before being removed after 102 pitches, his highest pitch count of the year. He's 3-0 in his last four starts.
Cashner takes a 3.38 ERA into Thursday's start in San Diego against the Mariners.
Rutledge went 0 for 6 and struck out twice in his first game with Colorado Springs after being optioned by the Rockies earlier this week. It was Rutledge's first work in Triple-A in his career.
Donaldson singled in the second, launched a solo home run in the fourth, reached on an infield single in the sixth and doubled in a run in the eighth. Donalson reached base five times and he finished 4 for 4 with a walk, two runs scored and two RBI in an 11-5 victory.
Donaldson is hitting .389 (21 for 54) with four home runs and seven RBI in his last 15 games played. He has a .322/.398/.544 slash line in 180 at-bats.
Castro launched a pair of solo home runs off starter A.J. Griffin in the first and fourth innings and also singled in a run in the sixth. He finished 3 for 4 with two runs scored and three RBI in an 11-5 defeat. Castro is hitting .265 with six home runs and 15 RBI.
His teammate Matt Dominguez also homered twice. It was the first time two Houston teammates have had multi-home run games since July 25, 2005, when Craig Biggio and Lance Berkman each had two.
Dominguez had solo shots in the third and seventh innings. He finished 2 for 4 with two runs scored and two RBI in an 11-5 loss. He has homered three times in his last two games since returning from a quad injury.
His teammate Jason Castro also homered twice. It was the first time two Houston teammates have had multi-home run games since July 25, 2005, when Craig Biggio and Lance Berkman each had two.