"I just kept aggravating it and throwing, and doing all the workouts and stuff," Santiago said. "It went on for longer than I wanted it to."
Santiago has been dealing with a back injury since the end of the spring, and Sunday's start against the Tigers was the first time he has taken the mound without a setback or flare-up. He is 0-3 with a 3.68 ERA in 22 innings of work.
Axford gave up a leadoff single in the ninth inning but then induced two ground balls for outs before a pop fly ended the game. He owns a 2.79 ERA and 9:7 K:BB ratio in 9 2/3 innings.
Vargas was handed a two-run lead going into the bottom of the second inning but gave it right back after surrendering a two-run triple. His unearned run came in the sixth when Michael Brantley stole second base and the Royals committed two errors trying to get him out. Vargas owns a sparkling 1.54 ERA and 18:8 K:BB ratio through 35 innings. He'll face the Blue Jays at home Tuesday.
Masterson gave up back-to-back home runs in the second inning, but he was able to hold the Royals to one unearned run the rest of the way. He owns a 4.50 ERA and 30:13 K:BB ratio in 28 innings. Masterson is slated to take on the Angels in Anaheim Monday.
Lindstrom was able to record the final out to strand the tying run on second base, and all three of his outs came via fly out. He owns a 2.70 ERA but just a 3:4 K:BB ratio in 10 innings.
Reed (0-1) loaded the bases in the seventh inning before being removed for another reliever, who served up a grand slam to the second batter he faced. Reed hadn't surrendered a run before Wednesday's loss. He owns a 3.52 ERA and 5:2 K:BB ratio in 7 2/3 innings.
Rienzo (1-0) was tagged for four runs in the fourth inning but was otherwise solid. He was on the hook for the loss before the White Sox delivered a go-ahead grand slam in the top of the seventh inning. Rienzo owns a 4.91 ERA and 4:3 K:BB ratio in 7 1/3 innings over his two appearances. His next test will come Monday against the Rays at home.
Smyly left the game with a 4-2 lead, but a seventh-inning grand slam by the White Sox took away his potential win. It was Smyly's first outing of more than three innings after beginning the season in the bullpen. He owns a 3.60 ERA and 15:4 K:BB ratio in 15 innings. Smyly is set to face the White Sox again Tuesday, this time in Chicago.
"We're going to try and be as accommodating as we can to get him as many at-bats, seeing as many pitches as possible on the front end of this thing," manager Bryan Price told MLB.com. "Once he goes to a full-season league, we can't control the environment."