Upton is batting .269 (7 for 26) with one RBI, two doubles, two walks and eight strikeouts in nine spring games.
Colon, who has been slowed by a calf injury, got off to a great start, tossing three scoreless innings. But he ran into trouble in the fourth inning, which started with a leadoff walk to Giancarlo Stanton. Ed Lucas had a two-RBI triple and Jake Marisnick had an RBI groundout off Colon in the fourth inning.
Colon (0-1) was charged with three runs on five hits and one walk, while striking out one. He opens the spring with a 6.75 ERA.
The left-handed hurler, who was making his second spring start and third appearance, improved to 1-0 by tossing three scoreless innings. He allowed three hits and one walk, while striking out a spring-high five batters.
Hand has allowed just one run in seven innings (1.29 ERA). He has nine strikeouts and has issued just two walks.
Bedard, who struck out one, entered the game in the fifth inning and retired the side in order. However, he ran into some trouble in the sixth, as Mike Napoli crushed a leadoff home run. A.J. Pierzynski had an RBI double and Will Middlebrooks added an RBI single in the sixth, as Boston sent eight batters to the plate.
Bedard has a 7.71 ERA through seven spring innings. He has more walks (five) than strikeouts (four).
The game was scoreless until Miguel Cabrera began a seven-run third inning with a two-run homer off Miller, who was then lifted from the game with one out in the third. Miller has a 5.40 ERA and nine strikeouts in five innings this spring.