Below are the 2012 salaries for the top 25 MLB players on active rosters and disabled lists as of March 31. This list was compiled using each player's base salary.
| Top 50 salaries | |||
| No. | Player/Team | Salary | |
| 1. | Alex Rodriguez, NYY | $29,000,000 | |
| 2. | Cliff Lee, PHI | $25,000,000 | |
| 3. | Johan Santana, NYM | $24,644,708 | |
| 4. | Mark Teixeira, NYY | $23,125,000 | |
| 5. | CC Sabathia, NYY | $23,000,000 | |
| 6. | Joe Mauer, MIN | $23,000,000 | |
| 7. | Prince Fielder, DET | $23,000,000 | |
| 8. | Tim Lincecum, SF | $22,250,000 | |
| 9. | Miguel Cabrera, DET | $21,000,000 | |
| 10. | Adrian Gonzalez, LAD | $21,000,000 | |
| 11. | Zack Greinke, LAD | $21,000,000 | |
| 12. | Vernon Wells, NYY | $21,000,000 | |
| 13. | Matt Cain, SF | $20,833,333 | |
| 14. | Cole Hamels, PHI | $20,500,000 | |
| 15. | Matt Kemp, LAD | $20,250,000 | |
| 16. | Justin Verlander, DET | $20,100,000 | |
| 17. | Carl Crawford, LAD | $20,000,000 | |
| 18. | Roy Halladay, PHI | $20,000,000 | |
| 19. | Ryan Howard, PHI | $20,000,000 | |
| 20. | Barry Zito, SF | $20,000,000 | |
| 21. | Felix Hernandez, SEA | $19,857,143 | |
| 22. | Alfonso Soriano, CHC | $19,000,000 | |
| 23. | Josh Hamilton, LAA | $17,400,000 | |
| 24. | Joey Votto, CIN | $17,000,000 | |
| 25. | Derek Jeter, NYY | $16,729,365 | |
| 26. | Jayson Werth, WAS | $16,571,429 | |
| 27. | A.J. Burnett, PIT | $16,500,000 | |
| 28. | Bronson Arroyo, CIN | $16,445,533 | |
| 29. | Matt Holliday, STL | $16,272,110 | |
| 30. | Jered Weaver, LAA | $16,200,000 | |
| 31. | Jake Peavy, CHW | $16,157,271 | |
| 32. | Albert Pujols, LAA | $16,000,000 | |
| 33. | Adrian Beltre, TEX | $16,000,000 | |
| 34. | John Lackey, BOS | $15,950,000 | |
| 35. | John Danks, CHW | $15,750,000 | |
| 35. | Josh Beckett, LAD | $15,750,000 | |
| 37. | Hanley Ramirez, LAD | $15,500,000 | |
| 38. | Nick Markakis, BAL | $15,350,000 | |
| 39. | Chase Utley, PHI | $15,285,714 | |
| 40. | Hiroki Kuroda, NYY | $15,000,000 | |
| 41. | Justin Morneau, MIN | $15,000,000 | |
| 42. | Adam Dunn, CHW | $15,000,000 | |
| 43. | Robinson Cano, NYY | $15,000,000 | |
| 44. | Curtis Granderson, NYY | $15,000,000 | |
| 45. | David Ortiz, BOS | $14,500,000 | |
| 46. | Yadier Molina, STL | $14,200,000 | |
| 47. | Ryan Zimmerman, WAS | $14,000,000 | |
| 48. | Jose Bautista, TOR | $14,000,000 | |
| 49. | Hunter Pence, SF | $13,800,000 | |
| 50. | Josh Johnson, TOR | $13,750,000 | |
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