| Basic Stats | Extended Stats |
| Saves | ||||||||||||||||||
| Player | Pos | Team | GP | GS | IP | W | L | SV | SVO | H | R | HR | ER | ERA | BB | K | TP | WHIP |
| Erik Bedard | SP | HOU | 9 | 7 | 33.0 | 0 | 2 | 1 | 1 | 37 | 22 | 9 | 22 | 6.00 | 15 | 34 | 641 | 1.58 |
| Drew Smyly | RP | DET | 15 | 0 | 28.0 | 2 | 0 | 1 | 2 | 20 | 6 | 0 | 6 | 1.93 | 7 | 29 | 471 | 0.96 |
| Tommy Hunter | RP | BAL | 16 | 0 | 25.1 | 3 | 1 | 1 | 1 | 15 | 5 | 4 | 4 | 1.42 | 4 | 19 | 383 | 0.75 |
| Aaron Loup | RP | TOR | 18 | 0 | 23.2 | 1 | 3 | 1 | 2 | 23 | 11 | 2 | 7 | 2.66 | 5 | 15 | 376 | 1.18 |
| Michael Kirkman | RP | TEX | 20 | 0 | 18.2 | 0 | 0 | 1 | 2 | 25 | 13 | 1 | 13 | 6.27 | 13 | 22 | 370 | 2.04 |
| Fernando Rodney | RP | TB | 18 | 0 | 18.0 | 1 | 2 | 9 | 12 | 13 | 10 | 2 | 10 | 5.00 | 16 | 25 | 360 | 1.61 |
| Jim Johnson | RP | BAL | 23 | 0 | 22.1 | 2 | 4 | 14 | 17 | 22 | 11 | 3 | 10 | 4.03 | 6 | 18 | 357 | 1.25 |
| Darren O'Day | RP | BAL | 21 | 0 | 20.2 | 2 | 0 | 1 | 3 | 15 | 5 | 1 | 4 | 1.74 | 9 | 22 | 356 | 1.16 |
| Ryan Cook | RP | OAK | 20 | 0 | 20.2 | 1 | 0 | 1 | 2 | 16 | 5 | 0 | 4 | 1.74 | 7 | 26 | 355 | 1.11 |
| Cody Allen | RP | CLE | 18 | 0 | 21.0 | 1 | 0 | 1 | 2 | 15 | 6 | 2 | 5 | 2.14 | 7 | 28 | 345 | 1.05 |
| Ernesto Frieri | RP | LAA | 18 | 0 | 20.0 | 0 | 1 | 9 | 10 | 9 | 5 | 3 | 5 | 2.25 | 15 | 28 | 335 | 1.20 |
| Addison Reed | RP | CHW | 21 | 0 | 21.0 | 1 | 0 | 16 | 17 | 14 | 5 | 0 | 5 | 2.14 | 8 | 24 | 332 | 1.05 |
| Grant Balfour | RP | OAK | 18 | 0 | 18.1 | 0 | 0 | 9 | 9 | 13 | 3 | 2 | 3 | 1.47 | 8 | 20 | 331 | 1.15 |
| Kelvin Herrera | RP | KC | 18 | 0 | 19.1 | 2 | 4 | 2 | 3 | 18 | 10 | 8 | 10 | 4.66 | 7 | 23 | 330 | 1.29 |
| Jared Burton | RP | MIN | 21 | 0 | 20.0 | 0 | 1 | 1 | 2 | 16 | 5 | 1 | 5 | 2.25 | 9 | 23 | 329 | 1.25 |
| Joel Peralta | RP | TB | 23 | 0 | 21.0 | 0 | 2 | 1 | 1 | 14 | 6 | 1 | 5 | 2.14 | 8 | 22 | 324 | 1.05 |
| Adam Warren | RP | NYY | 8 | 0 | 19.2 | 1 | 0 | 1 | 1 | 15 | 3 | 1 | 3 | 1.37 | 6 | 15 | 321 | 1.07 |
| Joaquin Benoit | RP | DET | 18 | 0 | 19.0 | 0 | 0 | 2 | 2 | 11 | 3 | 2 | 3 | 1.42 | 8 | 24 | 309 | 1.00 |
| Koji Uehara | RP | BOS | 19 | 0 | 17.2 | 0 | 0 | 1 | 2 | 14 | 4 | 3 | 4 | 2.04 | 4 | 26 | 290 | 1.02 |
| Chris Perez | RP | CLE | 16 | 0 | 16.0 | 2 | 0 | 6 | 8 | 13 | 5 | 4 | 4 | 2.25 | 7 | 18 | 288 | 1.25 |
| Joe Nathan | RP | TEX | 18 | 0 | 17.0 | 1 | 0 | 13 | 13 | 12 | 4 | 1 | 4 | 2.12 | 7 | 16 | 279 | 1.12 |
| Greg Holland | RP | KC | 16 | 0 | 15.0 | 1 | 1 | 7 | 9 | 13 | 7 | 0 | 5 | 3.00 | 8 | 24 | 277 | 1.40 |
| Mariano Rivera | RP | NYY | 19 | 0 | 18.1 | 0 | 0 | 17 | 17 | 14 | 3 | 1 | 3 | 1.47 | 2 | 14 | 271 | 0.87 |
| Tom Wilhelmsen | RP | SEA | 18 | 0 | 19.0 | 0 | 0 | 11 | 12 | 8 | 2 | 0 | 1 | 0.47 | 5 | 15 | 270 | 0.68 |
| Jose Veras | RP | HOU | 18 | 0 | 18.0 | 0 | 2 | 7 | 9 | 12 | 7 | 1 | 7 | 3.50 | 7 | 19 | 270 | 1.06 |
| Glen Perkins | RP | MIN | 16 | 0 | 15.2 | 1 | 0 | 8 | 9 | 10 | 6 | 2 | 6 | 3.45 | 5 | 25 | 264 | 0.96 |
| Joe Smith | RP | CLE | 17 | 0 | 16.0 | 2 | 0 | 1 | 1 | 10 | 2 | 1 | 2 | 1.13 | 4 | 16 | 232 | 0.88 |
| Luke Hochevar | RP | KC | 11 | 0 | 16.1 | 0 | 0 | 1 | 1 | 10 | 2 | 1 | 2 | 1.10 | 3 | 18 | 232 | 0.80 |
| Andrew Bailey | RP | BOS | 13 | 0 | 12.1 | 1 | 0 | 5 | 6 | 6 | 2 | 1 | 2 | 1.46 | 4 | 20 | 208 | 0.81 |
| Phil Coke | RP | DET | 13 | 0 | 13.1 | 0 | 3 | 1 | 2 | 13 | 11 | 1 | 11 | 7.43 | 6 | 12 | 207 | 1.43 |
| Aaron Crow | RP | KC | 15 | 0 | 12.2 | 0 | 0 | 1 | 1 | 7 | 2 | 1 | 2 | 1.42 | 4 | 8 | 205 | 0.87 |
| Casey Janssen | RP | TOR | 14 | 0 | 14.0 | 0 | 0 | 10 | 10 | 7 | 3 | 1 | 3 | 1.93 | 1 | 14 | 182 | 0.57 |
| Joel Hanrahan | RP | BOS | 9 | 0 | 7.1 | 0 | 1 | 4 | 6 | 10 | 8 | 4 | 8 | 9.82 | 6 | 5 | 160 | 2.18 |
| Joba Chamberlain | RP | NYY | 10 | 0 | 9.1 | 0 | 0 | 1 | 1 | 10 | 4 | 0 | 4 | 3.86 | 6 | 7 | 156 | 1.71 |
| Jose Valverde | RP | DET | 9 | 0 | 9.0 | 0 | 0 | 4 | 5 | 2 | 1 | 0 | 1 | 1.00 | 4 | 7 | 134 | 0.67 |
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