| Basic Stats | Extended Stats |
| Saves | ||||||||||||||||||
| Player | Pos | Team | GP | GS | IP | W | L | SV | SVO | H | R | HR | ER | ERA | BB | K | TP | WHIP |
| Joel Hanrahan | RP | BOS | 9 | 0 | 7.1 | 0 | 1 | 4 | 6 | 10 | 8 | 4 | 8 | 9.82 | 6 | 5 | 160 | 2.18 |
| Michael Kirkman | RP | TEX | 18 | 0 | 17.1 | 0 | 0 | 1 | 1 | 22 | 12 | 1 | 12 | 6.23 | 11 | 21 | 340 | 1.90 |
| Fernando Rodney | RP | TB | 16 | 0 | 15.1 | 1 | 2 | 7 | 10 | 12 | 9 | 2 | 9 | 5.28 | 15 | 23 | 328 | 1.76 |
| Joba Chamberlain | RP | NYY | 10 | 0 | 9.1 | 0 | 0 | 1 | 1 | 10 | 4 | 0 | 4 | 3.86 | 6 | 7 | 156 | 1.71 |
| Erik Bedard | SP | HOU | 9 | 7 | 33.0 | 0 | 2 | 1 | 1 | 37 | 22 | 9 | 22 | 6.00 | 15 | 34 | 641 | 1.58 |
| Greg Holland | RP | KC | 15 | 0 | 14.0 | 1 | 1 | 7 | 9 | 13 | 7 | 0 | 5 | 3.21 | 7 | 21 | 257 | 1.43 |
| Phil Coke | RP | DET | 12 | 0 | 12.2 | 0 | 3 | 1 | 2 | 11 | 9 | 1 | 9 | 6.39 | 6 | 12 | 191 | 1.34 |
| Kelvin Herrera | RP | KC | 17 | 0 | 18.1 | 2 | 3 | 2 | 3 | 17 | 9 | 7 | 9 | 4.42 | 7 | 23 | 319 | 1.31 |
| Jim Johnson | RP | BAL | 21 | 0 | 20.1 | 1 | 4 | 14 | 16 | 20 | 10 | 2 | 9 | 3.98 | 6 | 17 | 325 | 1.28 |
| Aaron Loup | RP | TOR | 17 | 0 | 22.0 | 1 | 3 | 1 | 2 | 22 | 11 | 2 | 7 | 2.86 | 5 | 13 | 349 | 1.23 |
| Darren O'Day | RP | BAL | 20 | 0 | 19.2 | 2 | 0 | 1 | 3 | 15 | 5 | 1 | 4 | 1.83 | 9 | 20 | 343 | 1.22 |
| Grant Balfour | RP | OAK | 17 | 0 | 17.1 | 0 | 0 | 8 | 8 | 13 | 3 | 2 | 3 | 1.56 | 8 | 19 | 319 | 1.21 |
| Jared Burton | RP | MIN | 19 | 0 | 18.0 | 0 | 1 | 1 | 2 | 14 | 3 | 0 | 3 | 1.50 | 7 | 20 | 286 | 1.17 |
| Chris Perez | RP | CLE | 15 | 0 | 15.0 | 2 | 0 | 6 | 8 | 12 | 4 | 3 | 3 | 1.80 | 5 | 16 | 260 | 1.13 |
| Joe Nathan | RP | TEX | 17 | 0 | 16.0 | 1 | 0 | 12 | 12 | 12 | 4 | 1 | 4 | 2.25 | 6 | 15 | 262 | 1.12 |
| Ernesto Frieri | RP | LAA | 17 | 0 | 18.2 | 0 | 1 | 8 | 9 | 9 | 4 | 3 | 4 | 1.93 | 12 | 28 | 308 | 1.12 |
| Jose Veras | RP | HOU | 17 | 0 | 17.0 | 0 | 2 | 6 | 8 | 12 | 7 | 1 | 7 | 3.71 | 7 | 17 | 254 | 1.12 |
| Addison Reed | RP | CHW | 19 | 0 | 19.0 | 1 | 0 | 14 | 15 | 13 | 5 | 0 | 5 | 2.37 | 8 | 22 | 307 | 1.11 |
| Cody Allen | RP | CLE | 17 | 0 | 19.1 | 1 | 0 | 1 | 2 | 15 | 6 | 2 | 5 | 2.33 | 6 | 24 | 318 | 1.09 |
| Adam Warren | RP | NYY | 8 | 0 | 19.2 | 1 | 0 | 1 | 1 | 15 | 3 | 1 | 3 | 1.37 | 6 | 15 | 321 | 1.07 |
| Aaron Crow | RP | KC | 13 | 0 | 10.2 | 0 | 0 | 1 | 1 | 7 | 2 | 1 | 2 | 1.69 | 4 | 7 | 186 | 1.03 |
| Joaquin Benoit | RP | DET | 18 | 0 | 19.0 | 0 | 0 | 2 | 2 | 11 | 3 | 2 | 3 | 1.42 | 8 | 24 | 309 | 1.00 |
| Joel Peralta | RP | TB | 21 | 0 | 19.2 | 0 | 2 | 1 | 1 | 12 | 5 | 1 | 4 | 1.83 | 7 | 20 | 290 | 0.97 |
| Drew Smyly | RP | DET | 15 | 0 | 28.0 | 2 | 0 | 1 | 2 | 20 | 6 | 0 | 6 | 1.93 | 7 | 29 | 471 | 0.96 |
| Glen Perkins | RP | MIN | 15 | 0 | 14.2 | 1 | 0 | 8 | 8 | 9 | 5 | 1 | 5 | 3.07 | 5 | 23 | 251 | 0.95 |
| Mariano Rivera | RP | NYY | 18 | 0 | 17.1 | 0 | 0 | 16 | 16 | 14 | 3 | 1 | 3 | 1.56 | 2 | 13 | 255 | 0.92 |
| Koji Uehara | RP | BOS | 18 | 0 | 16.2 | 0 | 0 | 1 | 2 | 12 | 4 | 3 | 4 | 2.16 | 3 | 23 | 267 | 0.90 |
| Luke Hochevar | RP | KC | 10 | 0 | 15.1 | 0 | 0 | 1 | 1 | 10 | 2 | 1 | 2 | 1.17 | 3 | 17 | 221 | 0.85 |
| Andrew Bailey | RP | BOS | 13 | 0 | 12.1 | 1 | 0 | 5 | 6 | 6 | 2 | 1 | 2 | 1.46 | 4 | 20 | 208 | 0.81 |
| Tommy Hunter | RP | BAL | 15 | 0 | 23.1 | 3 | 1 | 1 | 1 | 15 | 5 | 4 | 4 | 1.54 | 4 | 18 | 358 | 0.81 |
| Joe Smith | RP | CLE | 15 | 0 | 13.2 | 1 | 0 | 1 | 1 | 8 | 1 | 0 | 1 | 0.66 | 3 | 14 | 200 | 0.80 |
| Jose Valverde | RP | DET | 8 | 0 | 8.0 | 0 | 0 | 4 | 5 | 1 | 1 | 0 | 1 | 1.13 | 4 | 7 | 118 | 0.62 |
| Tom Wilhelmsen | RP | SEA | 17 | 0 | 18.0 | 0 | 0 | 11 | 11 | 6 | 1 | 0 | 1 | 0.50 | 5 | 13 | 248 | 0.61 |
| Casey Janssen | RP | TOR | 13 | 0 | 13.0 | 0 | 0 | 10 | 10 | 4 | 1 | 0 | 1 | 0.69 | 0 | 13 | 156 | 0.31 |
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