| Basic Stats | Extended Stats |
| Strikeouts | ||||||||||||||||||
| Player | Pos | Team | GP | GS | IP | W | L | SV | SVO | H | R | HR | ER | ERA | BB | K | TP | WHIP |
| Pat Neshek | RP | OAK | 18 | 0 | 16.0 | 0 | 0 | 0 | 0 | 17 | 7 | 1 | 5 | 2.81 | 8 | 11 | 280 | 1.56 |
| Greg Holland | RP | KC | 15 | 0 | 14.0 | 1 | 1 | 7 | 9 | 13 | 7 | 0 | 5 | 3.21 | 7 | 21 | 257 | 1.43 |
| Drew Smyly | RP | DET | 14 | 0 | 24.2 | 2 | 0 | 1 | 2 | 18 | 5 | 0 | 5 | 1.82 | 6 | 27 | 416 | 0.97 |
| Cody Allen | RP | CLE | 17 | 0 | 19.1 | 1 | 0 | 1 | 2 | 15 | 6 | 2 | 5 | 2.33 | 6 | 24 | 318 | 1.09 |
| Mike Adams | RP | PHI | 17 | 0 | 15.0 | 1 | 3 | 0 | 1 | 14 | 5 | 3 | 5 | 3.00 | 6 | 19 | 245 | 1.33 |
| Johnny Cueto | SP | CIN | 3 | 3 | 17.1 | 1 | 0 | 0 | 0 | 12 | 5 | 2 | 5 | 2.60 | 6 | 18 | 265 | 1.04 |
| Darren Oliver | RP | TOR | 16 | 0 | 16.0 | 2 | 1 | 0 | 1 | 18 | 7 | 1 | 5 | 2.81 | 6 | 9 | 240 | 1.50 |
| Kenley Jansen | RP | LAD | 21 | 0 | 21.1 | 1 | 1 | 2 | 2 | 15 | 5 | 2 | 5 | 2.11 | 5 | 29 | 350 | 0.94 |
| Glen Perkins | RP | MIN | 15 | 0 | 14.2 | 1 | 0 | 8 | 8 | 9 | 5 | 1 | 5 | 3.07 | 5 | 23 | 251 | 0.95 |
| Craig Stammen | RP | WAS | 11 | 0 | 20.0 | 2 | 1 | 0 | 1 | 15 | 5 | 1 | 5 | 2.25 | 5 | 22 | 293 | 1.00 |
| Adam Ottavino | RP | COL | 13 | 0 | 20.1 | 0 | 1 | 0 | 0 | 17 | 9 | 3 | 5 | 2.21 | 5 | 22 | 331 | 1.08 |
| Eric O'Flaherty | RP | ATL | 19 | 0 | 18.0 | 3 | 0 | 0 | 1 | 12 | 5 | 2 | 5 | 2.50 | 5 | 11 | 244 | 0.94 |
| Brett Marshall | RP | NYY | 1 | 0 | 5.2 | 0 | 0 | 0 | 0 | 9 | 5 | 2 | 5 | 7.94 | 5 | 1 | 108 | 2.47 |
| David Robertson | RP | NYY | 17 | 0 | 16.1 | 2 | 0 | 0 | 1 | 9 | 5 | 2 | 5 | 2.76 | 4 | 20 | 236 | 0.80 |
| Vin Mazzaro | RP | PIT | 14 | 0 | 15.2 | 2 | 0 | 0 | 1 | 16 | 5 | 1 | 5 | 2.87 | 4 | 12 | 247 | 1.28 |
| Ted Lilly | SP | LAD | 2 | 2 | 8.0 | 0 | 1 | 0 | 0 | 14 | 6 | 2 | 5 | 5.63 | 4 | 9 | 157 | 2.25 |
| Steven Wright | RP | BOS | 1 | 0 | 3.2 | 0 | 0 | 0 | 0 | 6 | 5 | 0 | 5 | 12.27 | 4 | 4 | 82 | 2.73 |
| Craig Kimbrel | RP | ATL | 16 | 0 | 15.1 | 0 | 1 | 12 | 15 | 13 | 5 | 3 | 5 | 2.93 | 3 | 23 | 239 | 1.04 |
| Brian Matusz | RP | BAL | 19 | 0 | 16.1 | 1 | 0 | 0 | 2 | 7 | 5 | 2 | 5 | 2.76 | 3 | 17 | 239 | 0.61 |
| Burke Badenhop | RP | MIL | 20 | 0 | 16.0 | 0 | 1 | 1 | 2 | 12 | 9 | 2 | 5 | 2.81 | 3 | 16 | 227 | 0.94 |
| Cesar Ramos | RP | TB | 15 | 0 | 15.2 | 1 | 0 | 0 | 0 | 12 | 5 | 1 | 5 | 2.87 | 3 | 10 | 205 | 0.96 |
| Jerry Blevins | RP | OAK | 19 | 0 | 19.2 | 2 | 0 | 0 | 2 | 13 | 5 | 2 | 5 | 2.29 | 1 | 20 | 299 | 0.71 |
| Liam Hendriks | SP | MIN | 2 | 2 | 9.2 | 0 | 1 | 0 | 0 | 12 | 5 | 1 | 5 | 4.66 | 1 | 5 | 190 | 1.34 |
| Josh Stinson | SP | BAL | 1 | 1 | 5.2 | 0 | 0 | 0 | 0 | 5 | 5 | 4 | 5 | 7.94 | 1 | 3 | 76 | 1.06 |
| Dave Bush | RP | TOR | 1 | 0 | 3.0 | 0 | 0 | 0 | 0 | 5 | 5 | 4 | 5 | 15.00 | 1 | 1 | 51 | 2.00 |
| Justin Wilson | RP | PIT | 15 | 0 | 25.2 | 4 | 0 | 0 | 2 | 9 | 4 | 0 | 4 | 1.40 | 14 | 25 | 427 | 0.90 |
| Santiago Casilla | RP | SF | 20 | 0 | 18.0 | 3 | 2 | 1 | 1 | 10 | 5 | 1 | 4 | 2.00 | 12 | 16 | 299 | 1.22 |
| Ryan Webb | RP | MIA | 17 | 0 | 23.0 | 1 | 1 | 0 | 0 | 9 | 6 | 0 | 4 | 1.57 | 11 | 14 | 321 | 0.87 |
| Antonio Bastardo | RP | PHI | 17 | 0 | 13.1 | 1 | 1 | 0 | 2 | 12 | 5 | 2 | 4 | 2.70 | 9 | 13 | 254 | 1.58 |
| Henry Rodriguez | RP | WAS | 11 | 0 | 11.2 | 0 | 0 | 0 | 0 | 7 | 4 | 1 | 4 | 3.09 | 9 | 9 | 221 | 1.37 |
| Tom Gorzelanny | RP | MIL | 18 | 0 | 15.2 | 1 | 0 | 0 | 1 | 6 | 4 | 2 | 4 | 2.30 | 8 | 10 | 221 | 0.89 |
| Luis Avilan | RP | ATL | 18 | 0 | 16.0 | 1 | 0 | 0 | 0 | 13 | 4 | 0 | 4 | 2.25 | 8 | 7 | 278 | 1.31 |
| Ryan Cook | RP | OAK | 18 | 0 | 18.2 | 1 | 0 | 0 | 1 | 14 | 5 | 0 | 4 | 1.93 | 7 | 23 | 316 | 1.12 |
| Bryan Shaw | RP | CLE | 16 | 0 | 19.1 | 0 | 0 | 0 | 0 | 16 | 6 | 1 | 4 | 1.86 | 7 | 20 | 330 | 1.19 |
| Mike Dunn | RP | MIA | 21 | 0 | 19.2 | 1 | 0 | 0 | 0 | 16 | 4 | 1 | 4 | 1.83 | 7 | 20 | 321 | 1.17 |
| Joel Peralta | RP | TB | 21 | 0 | 19.2 | 0 | 2 | 1 | 1 | 12 | 5 | 1 | 4 | 1.83 | 7 | 20 | 290 | 0.97 |
| Jeurys Familia | RP | NYM | 8 | 0 | 10.1 | 0 | 0 | 1 | 1 | 10 | 4 | 2 | 4 | 3.48 | 7 | 7 | 177 | 1.65 |
| Ramon Ortiz | SP | TOR | 3 | 2 | 15.1 | 1 | 1 | 0 | 0 | 15 | 4 | 0 | 4 | 2.35 | 7 | 4 | 241 | 1.43 |
| Joe Nathan | RP | TEX | 16 | 0 | 15.0 | 1 | 0 | 12 | 12 | 12 | 4 | 1 | 4 | 2.40 | 6 | 15 | 253 | 1.20 |
| Rich Hill | RP | CLE | 14 | 0 | 10.1 | 0 | 0 | 0 | 1 | 7 | 6 | 2 | 4 | 3.48 | 6 | 11 | 190 | 1.26 |
| Bryan Morris | RP | PIT | 9 | 0 | 12.2 | 1 | 1 | 0 | 0 | 7 | 4 | 2 | 4 | 2.84 | 6 | 8 | 183 | 1.03 |
| Joba Chamberlain | RP | NYY | 10 | 0 | 9.1 | 0 | 0 | 1 | 1 | 10 | 4 | 0 | 4 | 3.86 | 6 | 7 | 156 | 1.71 |
| Scott Downs | RP | LAA | 18 | 0 | 13.2 | 0 | 2 | 0 | 2 | 15 | 5 | 0 | 4 | 2.63 | 5 | 9 | 230 | 1.46 |
| Chad Billingsley | SP | LAD | 2 | 2 | 12.0 | 1 | 0 | 0 | 0 | 12 | 4 | 1 | 4 | 3.00 | 5 | 6 | 182 | 1.42 |
| Jim Johnson | RP | BAL | 20 | 0 | 20.0 | 1 | 3 | 14 | 15 | 17 | 5 | 1 | 4 | 1.80 | 4 | 17 | 293 | 1.05 |
| Yoervis Medina | RP | SEA | 10 | 0 | 11.0 | 0 | 0 | 0 | 0 | 6 | 4 | 0 | 4 | 3.27 | 4 | 14 | 171 | 0.91 |
| Jason Frasor | RP | TEX | 16 | 0 | 12.0 | 0 | 0 | 0 | 0 | 11 | 4 | 3 | 4 | 3.00 | 4 | 12 | 219 | 1.25 |
| Hector Noesi | RP | SEA | 5 | 1 | 13.2 | 0 | 0 | 0 | 0 | 13 | 5 | 0 | 4 | 2.63 | 4 | 10 | 217 | 1.24 |
| Phil Irwin | SP | PIT | 1 | 1 | 4.2 | 0 | 0 | 0 | 0 | 6 | 5 | 0 | 4 | 7.71 | 4 | 4 | 93 | 2.14 |
| Koji Uehara | RP | BOS | 18 | 0 | 16.2 | 0 | 0 | 1 | 2 | 12 | 4 | 3 | 4 | 2.16 | 3 | 23 | 267 | 0.90 |
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