All-time interleague club records
More interleague: Wins by league & attendance figures
Through 2010
| American League | |||
| Team | Games | W | L |
| Baltimore Orioles | 247 | 108 | 139 |
| Boston Red Sox | 247 | 140 | 107 |
| Chicago White Sox | 247 | 143 | 104 |
| Cleveland Indians | 247 | 118 | 129 |
| Detroit Tigers | 247 | 134 | 113 |
| Kansas City Royals | 247 | 115 | 132 |
| Los Angeles Angels | 248 | 139 | 109 |
| Minnesota Twins | 246 | 140 | 106 |
| New York Yankees | 246 | 144 | 102 |
| Oakland Athletics | 248 | 136 | 112 |
| Seattle Mariners | 248 | 136 | 112 |
| Tampa Bay Rays | 232 | 106 | 126 |
| Texas Rangers | 248 | 126 | 122 |
| Toronto Blue Jays | 247 | 115 | 132 |
| National League | |||
| Team | Games | W | L |
| Arizona Diamondbacks | 202 | 90 | 112 |
| Atlanta Braves | 226 | 119 | 107 |
| Chicago Cubs | 205 | 98 | 107 |
| Cincinnati Reds | 202 | 91 | 111 |
| Colorado Rockies | 208 | 103 | 105 |
| Florida Marlins | 234 | 127 | 107 |
| Houston Astros | 215 | 103 | 112 |
| Los Angeles Dodgers | 224 | 103 | 121 |
| Milwaukee Brewers | 199 | 93 | 106 |
| New York Mets | 229 | 118 | 111 |
| Philadelphia Phillies | 235 | 106 | 129 |
| Pittsburgh Pirates | 196 | 73 | 123 |
| St. Louis Cardinals | 205 | 109 | 96 |
| San Diego Padres | 224 | 97 | 127 |
| San Francisco Giants | 224 | 113 | 111 |
| Washington Nationals | 247 | 117 | 130 |
Notes: The Brewers went 8-7 as an AL club in interleague play in 1997. The Nationals' record includes totals for the Expos (1997-2004).
