It was the second and final extended spring game for Hughes, who will make his first regular season start Thursday against the Los Angeles Angels.
Hughes says he's "absolutely ready."
Hughes struck out six, throwing 56 of 84 pitches for strikes.
Gary Sanchez, a 17-year old Dominican catcher, had two of the hits -- both singles -- off Hughes.
A number of top Yankees prospects -- including outfielder Slade Heathcott, taken in the first round of the 2009 amateur draft -- played in the game.