New York manager Joe Girardi announced the plan for Pettitte before Wednesday night's game against Tampa Bay. Pettitte has been sidelined since June 19 by a strained left groin.
With his return, Javier Vazquez will shift to a long relief role.
A.J. Burnett will start the opener of a three-game series at Baltimore on Friday. CC Sabathia will pitch on Saturday, which also lines up the 19-game winner to face Tampa Bay's 17-game winner David Price five days later in the final game of a four-game series with the Rays at Yankee Stadium.
The Yankees signed left-hander Royce Ring to a major league contract. The left-hander joined the team on Wednesday.