Pedroia was rounding second base on Adrian Gonzalez's single to right, when he got his feet tangled up after hitting the bag. He fell and was able to scramble back safely. Pedroia was in obvious pain and limped back to Boston's dugout, accompanied by manager Terry Francona.
The team had no immediate word on Pedroia's condition.
Pedroia was the AL's MVP in 2008 and has been an All-Star the past three seasons. He came in batting .244 with two homers and 10 RBI. He had a run-scoring single Monday night in the third inning.