It will be Colon's first appearance since receiving a 50-game suspension for a positive testosterone test Aug. 22. The ban stretched into the first five games this season.
Also on Saturday, right-hander Will Harris was claimed off waivers by Arizona. He was claimed by the A's from Colorado on Wednesday.
Oakland also optioned starter Dan Straily, who had a career-high 11 strikeouts on Friday night, to Triple-A Sacramento.