Davies lasted just one-third of an inning in Monday's game against the Indians, and he was lifted after walking the bases loaded. He exited after 21 pitches (six strikes), led off the field by trainer Nick Kenney in the first inning of Kansas City's 19-1 loss.
Club officials said Davies left with soreness in his anterior shoulder. He was scheduled for a MRI, but the club immediately put him on the disabled list.
Davies motioned to the dugout after the third walk, and manager Ned Yost, pitching coach Bob McClure and Kenney came to the mound.
Rookie right-hander Nate Adcock replaced Davies and gave up a two-run single to Orlando Cabrera.
Right-hander Vin Mazzaro, who was scheduled to start Tuesday's game, replaced Adcock in the third with the Royals trailing 3-0, but the real trouble came in the fourth. Mazzaro gave up 10 runs on eight hits in the inning -- but Yost still didn't take him out.
Mazzaro gave up another run in the fourth, then left with the bases loaded. All three runners scored against right-hander Jeremy Jeffress, leaving Mazzaro charged with 14 runs on 11 hits in 2 1/3 innings.
He became only the third pitcher since 1947 to surrender 14 earned runs in a game, and the first to give up 10 runs in an inning since Texas' Scott Feldman did it in 2008 against Boston, according to STATS LLC.
Afterward, Mazzaro was optioned to Class AAA Omaha. Sean O'Sullivan was bumped up from Wednesday to Tuesday in the rotation, though he will still be starting on his regular fifth day due to a rainout Sunday in Detroit.
Davies' ERA jumped to 7.46 after two runs were charged against him. He dropped to 1-6 in nine starts.
Davies joins fellow starter Bruce Chen (left lat tightness) on the disabled list.
Mazzaro's ERA went from 4.50 to 22.74.
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