| Last updated: Mon, November 9, 2009, 16:30 EST |
| Date | Player | Pos. | Transaction |
| 11/6 | Tomo Ohka | P | Declared Free Agency |
| 11/6 | Jamey Carroll | 2B | Declared Free Agency |
| 10/30 | Mike Gosling | P | Outrighted to Minors |
| 10/30 | Scott Lewis | P | Outrighted to Minors |
| 10/30 | Niuman Romero | SS | Outrighted to Minors |
| 10/14 | Grady Sizemore | CF | Removed From 15-Day DL, (Left elbow and lower abdominal surgery) |
| 10/14 | Joe Smith | P | Removed From 15-Day DL, (Sprained left knee) |
| 9/24 | Rich Rundles | P | Called Up from Minors, - Not to Report |
| 9/24 | Rich Rundles | P | Outrighted to Minors |
| 9/24 | R.J. Swindle | P | Outrighted to Minors |
| 9/24 | R.J. Swindle | P | Called Up from Minors, - Not to Report |
| 9/24 | Zach Jackson | P | Called Up from Minors, - Not to Report |
| 9/24 | Zach Jackson | P | Outrighted to Minors |
| 9/23 | Joe Smith | P | Removed From 15-Day DL, (Sprained left knee) |
| 9/14 | Joe Smith | P | Placed on 15-Day DL, (Sprained left knee) |
| 9/12 | Grady Sizemore | CF | Placed on 15-Day DL, (Left elbow and lower abdominal surgeries) |
| 9/8 | Niuman Romero | SS | Purchased From Minors |
| 9/7 | Lou Marson | C | Called Up from Minors |
| 9/4 | Trevor Crowe | CF | Removed From 15-Day DL, (Right internal oblique strain) |
| 9/4 | Mike Gosling | P | Purchased From Minors |
| 9/1 | Carlos Carrasco | P | Called Up from Minors |
| 9/1 | Michael Brantley | CF | Purchased From Minors |
| 9/1 | Jose Veras | P | Purchased From Minors |
| 8/19 | Matt LaPorta | LF | Called Up from Minors |
| 8/19 | Trevor Crowe | CF | Placed on 15-Day DL, (Right internal oblique strain) |
| 8/17 | Scott Lewis | P | Removed From 60-Day DL, (Left elbow strain - out 2-4 weeks) |
| 8/17 | Scott Lewis | P | Recalled From Minors, Rehab Assignment |
| 8/17 | Scott Lewis | P | Sent to Minors |
| 8/15 | Scott Lewis | P | Sent to Minors, For Rehabilitation |
| 8/12 | R.J. Swindle | P | Sent to Minors |
| 8/12 | R.J. Swindle | P | Acquired Off Waivers From, Tampa Bay |
| 8/11 | Josh Barfield | 2B | Outrighted to Minors |
| 8/11 | Josh Barfield | 2B | Called Up from Minors, - Not to Report |
| 8/11 | Jose Veras | P | Outrighted to Minors |
| 8/7 | Rafael Perez | P | Called Up from Minors |
| 8/6 | Mike Gosling | P | Outrighted to Minors |
| 8/6 | Winston Abreu | P | Refused Minor League Assignment - Free Agent |
| 8/6 | Winston Abreu | P | Outrighted to Minors |
| 8/5 | Jess Todd | P | Called Up from Minors |
| 8/5 | Jose Veras | P | Designated for Assignment |
| 8/1 | Winston Abreu | P | Designated for Assignment |
| 8/1 | Mike Gosling | P | Designated for Assignment |
| 8/1 | Jensen Lewis | P | Called Up from Minors |
| 7/31 | Wyatt Toregas | C | Called Up from Minors |
| 7/31 | Justin Masterson | P | Traded From, Boston (for C Victor Martinez, four-player deal) |
| 7/30 | Trevor Crowe | LF | Called Up from Minors |
| 7/30 | Fausto Carmona | P | Called Up from Minors |
| 7/29 | Lou Marson | C | Traded From, Philadelphia (for LHP Cliff Lee, six-player deal) |
| 7/29 | Lou Marson | C | Sent to Minors |
| 7/29 | Carlos Carrasco | P | Traded From, Philadelphia (for LHP Cliff Lee, six-player deal) |
| 7/29 | Carlos Carrasco | P | Sent to Minors |
| 7/28 | Andy Marte | 3B | Purchased From Minors |
| 7/27 | Winston Abreu | P | Suspension Announced By League, (three games) |
| 7/26 | Jess Todd | P | Traded From, St. Louis (completes 6/27 Mark DeRosa trade) |
| 7/26 | Jess Todd | P | Sent to Minors |
| 7/25 | Jeremy Sowers | P | Called Up from Minors |
| 7/19 | Masa Kobayashi | P | Released |
| 7/13 | Matt Herges | P | Released |
| 7/9 | Rafael Betancourt | P | Removed From 15-Day DL, (Right groin strain) |
| 7/9 | Rafael Betancourt | P | Recalled From Minors, Rehab Assignment |
| 7/9 | Jeremy Sowers | P | Sent to Minors |
| 7/8 | Rafael Perez | P | Sent to Minors |
| 7/8 | Aaron Laffey | P | Recalled From Minors, Rehab Assignment |
| 7/8 | Aaron Laffey | P | Removed From 15-Day DL, (Right oblique strain - out 6-8 weeks) |
| 7/7 | Michael Tejera | P | Signed to a Minor League Contract |
| 7/4 | Matt Herges | P | Designated for Assignment |
| 7/4 | Bobby Livingston | P | Signed to a Minor League Contract |
| 7/3 | Rafael Betancourt | P | Sent to Minors, For Rehabilitation |
| 7/2 | John Meloan | P | Called Up from Minors, - Not to Report |
| 7/2 | Winston Abreu | P | Traded From, Tampa Bay (for RHP John Meloan and cash) |
| 6/30 | Luis Vizcaino | P | Released |
| 6/29 | Josh Barfield | 2B | Sent to Minors |
| 6/28 | Asdrubal Cabrera | 2B | Recalled From Minors, Rehab Assignment |
| 6/28 | Asdrubal Cabrera | 2B | Removed From 15-Day DL, (Dislocated left shoulder) |
| 6/27 | Chris Perez | P | Traded From, St. Louis (w/player to be named for INF Mark DeRosa) |
| 6/26 | Jensen Lewis | P | Sent to Minors |
| 6/24 | Jose Veras | P | Traded From, NY Yankees (for cash considerations) |
| 6/23 | Grady Sizemore | CF | Removed From 15-Day DL, (Left elbow inflammation) |
| 6/23 | Luis Vizcaino | P | Designated for Assignment |
| 6/23 | Tony Sipp | P | Called Up from Minors |
| 6/23 | Trevor Crowe | LF | Sent to Minors |
| 6/23 | Asdrubal Cabrera | 2B | Sent to Minors, For Rehabilitation |
| 6/23 | Greg Aquino | P | Outrighted to Minors |
| 6/19 | Greg Aquino | P | Designated for Assignment |
| 6/19 | Mike Gosling | P | Purchased From Minors |
| 6/18 | Aaron Laffey | P | Sent to Minors, For Rehabilitation |
| 6/11 | Scott Lewis | P | Sent to Minors, For Rehabilitation |
| 6/9 | Tony Sipp | P | Sent to Minors |
| 6/9 | Joe Smith | P | Removed From 15-Day DL, (Strained right rotator cuff) |
| 6/9 | Joe Smith | P | Recalled From Minors, Rehab Assignment |
| 6/6 | Rob Mackowiak | LF | Signed to a Minor League Contract |
| 6/6 | Jake Westbrook | P | Sent to Minors, For Rehabilitation |
| 6/5 | Travis Hafner | DH | Removed From 15-Day DL, (Right shoulder soreness) |
| 6/5 | Fausto Carmona | P | Sent to Minors |
| 6/5 | Travis Hafner | DH | Recalled From Minors, Rehab Assignment |
| 6/3 | Asdrubal Cabrera | 2B | Placed on 15-Day DL, (Dislocated left shoulder) |
| 6/3 | Josh Barfield | 2B | Called Up from Minors |
| 6/1 | Rafael Betancourt | P | Placed on 15-Day DL, (Right groin strain) |
| 6/1 | Tony Sipp | P | Called Up from Minors |
| 6/1 | David Dellucci | LF | Released |
| 5/31 | Chris Gimenez | C | Called Up from Minors |
| 5/31 | Grady Sizemore | CF | Placed on 15-Day DL, (Left elbow inflammation) |
| 5/29 | Joe Smith | P | Sent to Minors, For Rehabilitation |
| 5/29 | Kenny Ray | P | Signed to a Minor League Contract |
| 5/29 | Rafael Perez | P | Called Up from Minors |
| 5/29 | David Dellucci | LF | Designated for Assignment |
| 5/28 | Anthony Reyes | P | Transferred to 60-Day DL, (Right elbow inflammation) |
| 5/28 | Tomo Ohka | | Purchased From Minors |
| 5/28 | Zach Jackson | P | Sent to Minors |
| 5/27 | Zach Jackson | P | Called Up from Minors |
| 5/27 | Rich Rundles | P | Sent to Minors |
| 5/26 | Matt LaPorta | LF | Sent to Minors |
| 5/26 | Trevor Crowe | LF | Called Up from Minors |
| 5/25 | Travis Hafner | DH | Recalled From Minors, Rehab Assignment |
| 5/23 | Anthony Reyes | P | Placed on 15-Day DL, (Right elbow inflammation) |
| 5/23 | Jeremy Sowers | P | Called Up from Minors |
| 5/23 | Rich Rundles | P | Called Up from Minors |
| 5/23 | Aaron Laffey | P | Placed on 15-Day DL, (Right oblique strain - out 6-8 weeks) |
| 5/17 | David Huff | P | Purchased From Minors |
| 5/17 | Greg Aquino | P | Purchased From Minors |
| 5/17 | Scott Lewis | P | Transferred to 60-Day DL, (Left elbow strain - out 2-4 weeks) |
| 5/17 | Tony Sipp | P | Sent to Minors |
| 5/16 | Masa Kobayashi | P | Outrighted to Minors |
| 5/14 | Vinnie Chulk | P | Outrighted to Minors |
| 5/14 | Luis Vizcaino | P | Signed as Free Agent, ( 2009) |
| More Transactions |