Cabrera said he felt "a little pop" in his right quadriceps as he ran to first base on a fifth-inning ground ball. The Indians will send Cabrera back to Cleveland on Tuesday morning for further tests, but it's almost certain he will miss significant time.
Mike Aviles will fill in at shortstop for whatever time Cabrera is out.
Cabrera wasn't able to put any weight on the leg as he came off the field. He was walking gingerly in the Indians clubhouse after the game, a 7-4 Yankee win.
"I'm a little bit [worried]," Cabrera said.
Cabrera has been playing with a sore quad for a couple of weeks, but he said he had been feeling good the last couple of days.
Cabrera bats third for the Indians, who began the night just half a game behind the Tigers in the American League Central.
"Mike Aviles will shine," manager Terry Francona predicted. "I have no doubt. You don't like to lose any players, but you don't like to use it as an excuse."
Francisco Lindor, one of the Indians' top prospects, is a shortstop who is doing well at Class A Carolina. But the Indians don't believe he's ready to play in the major leagues yet.