Earl Boykins added 17 points and seven assists for Denver, which led 63-48 at halftime and 93-72 after three periods. Nene had 14 points and 12 rebounds for the Nuggets, who hit 10 3-pointers.
Jason Maxiell led the Pistons with 21 points. Nazr Mohammed added 16 points and 12 rebounds despite picking up three fouls in the first quarter.
The game drew 15,810 fans with the Tigers home for Game 2 of the World Series against the St. Louis Cardinals.