Williams made two free throws to give the Jazz an 87-58 advantage with 4:46 left in the third quarter before sitting out the rest of the game. None of the Jazz starters played more than 23 minutes.
Matt Harpring scored 13 points for Utah and Carlos Boozer had 10 before fouling out in a game in which the teams combined for 73 fouls. Andrei Kirilenko and Ronnie Brewer each added 13 points for the Jazz, who evened their exhibition record at 4-4.
Al Harrington scored 24 points in 24 minutes and Stephen Jackson added 19 points for Indiana, which finished 3-5 in exhibition play.
The Pacers had three technical fouls in the first seven minutes. Jeff Foster also received a flagrant foul when he slammed into Brewer late in the first quarter.
Led by Kirilenko's nine points in the first quarter, the Jazz led 40-26 after their highest-scoring period of the exhibition season, and never trailed again.
The lead reached 29 points in the second quarter as the Pacers committed 17 first-half turnovers that led to 21 Jazz points. The sloppy Pacers finished with 30 miscues after posting 31 turnovers in their 109-96 loss to Charlotte on Tuesday.
Derek Fisher missed the game for Utah with a bruised pelvis and Mehmet Okur was out with a sore left hip flexor, but both should return when the regular season begins next week.