Lillard had 18 during the third quarter, when the Trail Blazers (4-2) opened a 19-point lead. Reserve Mo Williams added 17 points for Portland.
Patrick Patterson scored 27 points for Sacramento (3-2), and Isiah Thomas had 15. Ben McLemore scored 21 of his 23 in the second half.
Portland outrebounded Sacramento 54-40, led by Nicolas Batum's 11 boards.