Davis scored 11 points on 5-of-7 shooting and had six rebounds in the first half when the Hornets took a 64-39 lead Monday. It was unclear when the injury occurred, but Davis limped to the locker room at the break.
A stress fracture in the same ankle forced Davis to miss 11 games earlier in the season.
He is averaging 13.2 points and 8 rebounds. Davis was the first pick in last year's NBA draft.