The Heat are seeking their 27th consecutive victory Monday night against the Orlando Magic. Guard Mike Miller will start again in his place.
Wade sat out Miami's victory against Charlotte on Sunday night. Spoelstra says that Wade is feeling "a lot better" but that they don't want to risk him aggravating the injury further.
Wade will be reevaluated on Tuesday.
Wade has appeared in 64 games this season and is second in scoring behind LeBron James, averaging 21.5 points, 5.0 rebounds and 5.0 assists per game.