The Clippers announced the deal Friday for Wayns, an undrafted rookie from Villanova.
Wayns has appeared in three games for Los Angeles, averaging 3.7 points and 2.3 assists. The Clippers signed him from the Rio Grande Valley Vipers of the D-League on March 9.
He started the season with the 76ers, appearing in 21 games and never cracking their rotation.
Although the Clippers are one of the NBA's deepest teams, Los Angeles guard Chauncey Billups strained his groin during the Clippers' win at New Orleans on Wednesday. His return is uncertain heading into Friday's game at San Antonio.